Somatotopic Configuration of Distal Residual Limb Tissues in Lower Extremity Amputations

NACompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

September 15, 2017

Primary Completion Date

September 30, 2024

Study Completion Date

September 30, 2024

Conditions
Amputation
Interventions
PROCEDURE

Modified amputation procedure

A stair-step (BKA) or fishmouth (AKA) incision will be made. Tibial and fibular or femoral osteotomies will be performed. Segments of the tibialis anterior (TA), peroneus longus (PL), lateral gastrocnemius (LG) and tibialis posterior (TP) muscles will be isolated, as well as the quadriceps (Q) and hamstring (H) groups in the AKA model; if it is not possible to preserve native innervation to these muscles, functional motor units will be constructed from muscle coapted to the appropriate motor nerve endings. The distal tibial and peroneal nerves will be redirected to skin patches in the distal or proximal thigh. Coaptation of the TA/LG, PL/TP and Q/H muscles will then be performed to promote dynamic coupling of these agonist/antagonist pairs. The skin envelope will then be closed in layers over percutaneous drains.

Trial Locations (2)

02114

Brigham & Women's Hospital, Boston

02139

Massachusetts Institute of Technology Media Lab, Cambridge

All Listed Sponsors
collaborator

Massachusetts Institute of Technology

OTHER

collaborator

Massachusetts General Hospital

OTHER

lead

Brigham and Women's Hospital

OTHER

NCT03374319 - Somatotopic Configuration of Distal Residual Limb Tissues in Lower Extremity Amputations | Biotech Hunter | Biotech Hunter