324
Participants
Start Date
June 20, 2018
Primary Completion Date
March 1, 2026
Study Completion Date
March 1, 2026
Apalutamide
Given PO
External Beam Radiation Therapy
Undergo external beam radiation therapy
Placebo Administration
Given PO
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
James J Peters VA Medical Center, The Bronx
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn
Stony Brook University Medical Center, Stony Brook
State University of New York Upstate Medical University, Syracuse
Mary Imogene Bassett Hospital, Cooperstown
Sands Cancer Center, Canandaigua
Wilmot Cancer Institute Radiation Oncology at Greece, Rochester
Highland Hospital, Rochester
University of Rochester, Rochester
UPMC-Heritage Valley Health System Beaver, Beaver
UPMC Hillman Cancer Center in Coraopolis, Moon Township
UPMC Cancer Center at UPMC McKeesport, McKeesport
UPMC Cancer Center - Monroeville, Monroeville
UPMC-Magee Womens Hospital, Pittsburgh
UPMC-Saint Margaret, Pittsburgh
UPMC-Shadyside Hospital, Pittsburgh
UPMC-Passavant Hospital, Pittsburgh
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh
UPMC Washington Hospital Radiation Oncology, Washington
UPMC Uniontown Hospital Radiation Oncology, Uniontown
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg
UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown
UPMC Cancer Center at UPMC Horizon, Farrell
UPMC Cancer Center at UPMC Northwest, Seneca
UPMC Altoona, Altoona
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem
Northeast Radiation Oncology Center, Dunmore
Guthrie Medical Group PC-Robert Packer Hospital, Sayre
Asplundh Cancer Pavilion, Willow Grove
Thomas Jefferson University Hospital, Philadelphia
Fox Chase Cancer Center, Philadelphia
Jefferson Torresdale Hospital, Philadelphia
Christiana Care Health System-Concord Health Center, Chadds Ford
Reading Hospital, West Reading
Helen F Graham Cancer Center, Newark
Christiana Care Health System-Christiana Hospital, Newark
Beebe Health Campus, Rehoboth Beach
George Washington University Medical Center, Washington D.C.
Central Maryland Radiation Oncology in Howard County, Columbia
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie
University of Maryland/Greenebaum Cancer Center, Baltimore
Saint Agnes Hospital, Baltimore
Hunter Holmes McGuire Veterans Administration Medical Center, Richmond
Camden Clark Medical Center, Parkersburg
West Virginia University Healthcare, Morgantown
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Novant Health Cancer Institute Radiation Oncology - Wilmington, Wilmington
Novant Health New Hanover Regional Medical Center, Wilmington
Novant Cancer Institute Radiation Oncology - Supply, Supply
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
Prisma Health Cancer Institute - Faris, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Self Regional Healthcare, Greenwood
Prisma Health Cancer Institute - Greer, Greer
Prisma Health Cancer Institute - Seneca, Seneca
The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island
Grady Health System, Atlanta
Emory University Hospital Midtown, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Emory Saint Joseph's Hospital, Atlanta
Northside Hospital, Atlanta
Augusta University Medical Center, Augusta
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah
AdventHealth Altamonte, Altamonte Springs
AdventHealth Winter Park, Winter Park
AdventHealth Orlando, Orlando
AdventHealth East Orlando, Orlando
Cleveland Clinic-Weston, Weston
Regional Cancer Center-Lee Memorial Health System, Fort Myers
AdventHealth Kissimmee, Kissimmee
Vanderbilt University/Ingram Cancer Center, Nashville
The West Clinic - Wolf River, Germantown
University of Mississippi Medical Center, Jackson
University of Kentucky/Markey Cancer Center, Lexington
Ohio State University Comprehensive Cancer Center, Columbus
The Mark H Zangmeister Center, Columbus
Geauga Hospital, Chardon
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
Case Western Reserve University, Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
UHHS-Chagrin Highlands Medical Center, Beachwood
Hillcrest Hospital Cancer Center, Mayfield Heights
University Hospitals Parma Medical Center, Parma
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights
Cleveland Clinic Cancer Center Strongsville, Strongsville
UHHS-Westlake Medical Center, Westlake
Cleveland Clinic Foundation, Cleveland
University Hospitals Portage Medical Center, Ravenna
Summa Health System - Akron Campus, Akron
Cleveland Clinic Akron General, Akron
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster
North Coast Cancer Care, Sandusky
UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky
Cleveland Clinic Cancer Center Mansfield, Mansfield
Dayton Physicians LLC-Atrium, Franklin
University of Cincinnati Cancer Center-West Chester, West Chester
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
Oncology Hematology Care Inc-Kenwood, Cincinnati
Dayton Physicians LLC-Wayne, Greenville
Wayne Hospital, Greenville
Dayton Physicians LLC - Troy, Troy
Upper Valley Medical Center, Troy
Good Samaritan Hospital - Dayton, Dayton
Miami Valley Hospital, Dayton
Greater Dayton Cancer Center, Kettering
Dayton Physician LLC - Englewood, Dayton
Miami Valley Hospital North, Dayton
First Dayton Cancer Care, Kettering
Kettering Medical Center, Kettering
Indu and Raj Soin Medical Center, Beavercreek
Dayton Physicians LLC-Miami Valley South, Centerville
Miami Valley Hospital South, Centerville
Springfield Regional Cancer Center, Springfield
Springfield Regional Medical Center, Springfield
Armes Family Cancer Center, Findlay
Blanchard Valley Hospital, Findlay
Orion Cancer Care, Findlay
Goshen Center for Cancer Care, Goshen
Parkview Hospital Randallia, Fort Wayne
Parkview Regional Medical Center, Fort Wayne
Reid Health, Richmond
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
Corewell Health William Beaumont University Hospital, Royal Oak
Corewell Health Beaumont Troy Hospital, Troy
Michigan Healthcare Professionals Troy, Troy
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
University of Michigan Comprehensive Cancer Center, Ann Arbor
Trinity Health Medical Center - Brighton, Brighton
Chelsea Hospital, Chelsea
Corewell Health Dearborn Hospital, Dearborn
Trinity Health Medical Center - Canton, Canton
Henry Ford Hospital, Detroit
Henry Ford West Bloomfield Hospital, West Bloomfield
Michigan Healthcare Professionals Farmington, Farmington Hills
Michigan Healthcare Professionals Clarkston, Clarkston
Michigan State University, East Lansing
University of Michigan Health - Sparrow Lansing, Lansing
West Michigan Cancer Center, Kalamazoo
Bronson Battle Creek, Battle Creek
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
University of Michigan Health - West, Wyoming
Corewell Health Reed City Hospital, Reed City
Munson Medical Center, Traverse City
Mercy Medical Center-West Lakes, West Des Moines
Mercy Medical Center - Des Moines, Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
Mercy Cancer Center-West Lakes, Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
Greater Regional Medical Center, Creston
Aurora Cancer Care-Grafton, Grafton
Froedtert Menomonee Falls Hospital, Menomonee Falls
Aurora Medical Center in Summit, Summit
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend
Aurora Cancer Care-Kenosha South, Kenosha
Aurora Saint Luke's Medical Center, Milwaukee
Medical College of Wisconsin, Milwaukee
Aurora West Allis Medical Center, West Allis
Zablocki Veterans Administration Medical Center, Milwaukee
Cancer Center of Western Wisconsin, New Richmond
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
Aurora BayCare Medical Center, Green Bay
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center - Weston, Weston
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Marshfield Medical Center - Minocqua, Minocqua
Marshfield Medical Center-EC Cancer Center, Eau Claire
Marshfield Medical Center-Rice Lake, Rice Lake
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
Lakeview Hospital, Stillwater
Fairview Lakes Medical Center, Wyoming
Regions Hospital, Saint Paul
United Hospital, Saint Paul
Minnesota Oncology Hematology PA-Maplewood, Maplewood
Saint John's Hospital - Healtheast, Maplewood
Minnesota Oncology Hematology PA-Woodbury, Woodbury
Fairview Ridges Hospital, Burnsville
Monticello Cancer Center, Monticello
Fairview Clinics and Surgery Center Maple Grove, Maple Grove
Saint Francis Regional Medical Center, Shakopee
Ridgeview Medical Center, Waconia
Abbott-Northwestern Hospital, Minneapolis
Hennepin County Medical Center, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
Minneapolis VA Medical Center, Minneapolis
North Memorial Medical Health Center, Robbinsdale
Unity Hospital, Fridley
Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
Health Partners Inc, Minneapolis
Mayo Clinic in Rochester, Rochester
Mayo Clinic Health Systems-Mankato, Mankato
Mayo Clinic Health System in Albert Lea, Albert Lea
Rice Memorial Hospital, Willmar
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud
Rapid City Regional Hospital, Rapid City
Billings Clinic Cancer Center, Billings
Benefis Sletten Cancer Institute, Great Falls
Bozeman Health Deaconess Hospital, Bozeman
Edward Hines Jr VA Hospital, Hines
Loyola University Medical Center, Maywood
Rush University Medical Center, Chicago
University of Illinois, Chicago
Illinois CancerCare-Peoria, Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria
OSF Saint Francis Medical Center, Peoria
Carle Cancer Center, Urbana
Crossroads Cancer Center, Effingham
Decatur Memorial Hospital, Decatur
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Springfield Memorial Hospital, Springfield
Washington University School of Medicine, St Louis
Siteman Cancer Center-South County, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Mercy Hospital Saint Louis, St Louis
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
Mercy Cancer Center - Cape Girardeau, Cape Girardeau
University of Kansas Cancer Center - Lee's Summit, Lee's Summit
Kansas City Veterans Affairs Medical Center, Kansas City
University of Kansas Cancer Center - North, Kansas City
MU Health Care Goldschmidt Cancer Center, Jefferson City
Phelps Health Delbert Day Cancer Institute, Rolla
The University of Kansas Cancer Center - Olathe, Olathe
University of Kansas Cancer Center, Kansas City
University of Kansas Hospital-Westwood Cancer Center, Westwood
University of Kansas Cancer Center-Overland Park, Overland Park
Salina Regional Health Center, Salina
Nebraska Methodist Hospital, Omaha
Alegent Health Bergan Mercy Medical Center, Omaha
University of Nebraska Medical Center, Omaha
East Jefferson General Hospital, Metairie
LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie
Mary Bird Perkins Cancer Center, Baton Rouge
University of Arkansas for Medical Sciences, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
Cancer Treatment Centers of America, Tulsa
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Audie L Murphy VA Hospital, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
UCHealth University of Colorado Hospital, Aurora
Poudre Valley Hospital, Fort Collins
Cancer Care and Hematology-Fort Collins, Fort Collins
Medical Center of the Rockies, Loveland
UCHealth Greeley Hospital, Greeley
Penrose-Saint Francis Healthcare, Colorado Springs
UCHealth Memorial Hospital Central, Colorado Springs
Memorial Hospital North, Colorado Springs
Valley View Hospital Cancer Center, Glenwood Springs
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
Saint Luke's Cancer Institute - Fruitland, Fruitland
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Luke's Cancer Institute - Boise, Boise
American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork
Farmington Health Center, Farmington
Riverton Hospital, Riverton
Utah Cancer Specialists-Salt Lake City, Salt Lake City
Intermountain Medical Center, Murray
Huntsman Cancer Institute/University of Utah, Salt Lake City
LDS Hospital, Salt Lake City
Logan Regional Hospital, Logan
McKay-Dee Hospital Center, Ogden
Utah Valley Regional Medical Center, Provo
Sandra L Maxwell Cancer Center, Cedar City
Saint George Regional Medical Center, St. George
Arizona Center for Cancer Care - Scottsdale, Scottsdale
Arizona Center for Cancer Care - Gilbert, Gilbert
Arizona Center for Cancer Care-Surprise, Surprise
Arizona Center for Cancer Care-Peoria, Peoria
University of New Mexico Cancer Center, Albuquerque
New Mexico Oncology Hematology Consultants, Albuquerque
Hope Cancer Care of Nevada-Pahrump, Pahrump
Comprehensive Cancer Centers of Nevada - Henderson, Henderson
Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson
Las Vegas Cancer Center-Henderson, Henderson
OptumCare Cancer Care at Seven Hills, Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson
GenesisCare USA - Henderson, Henderson
Desert West Surgery, Las Vegas
OptumCare Cancer Care at Charleston, Las Vegas
University Medical Center of Southern Nevada, Las Vegas
Hope Cancer Care of Nevada, Las Vegas
Radiation Oncology Centers of Nevada Central, Las Vegas
GenesisCare USA - Las Vegas, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas
Radiation Oncology Centers of Nevada Southeast, Las Vegas
Cancer Therapy and Integrative Medicine, Las Vegas
Ann M Wierman MD LTD, Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas
GenesisCare USA - Vegas Tenaya, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas
OptumCare Cancer Care at MountainView, Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas
Summerlin Hospital Medical Center, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
GenesisCare USA - Fort Apache, Las Vegas
OptumCare Cancer Care at Fort Apache, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas
University Cancer Center, Las Vegas
Radiation Oncology Associates, Reno
Los Angeles General Medical Center, Los Angeles
USC / Norris Comprehensive Cancer Center, Los Angeles
Cedars Sinai Medical Center, Los Angeles
Sutter Solano Medical Center/Cancer Center, Vallejo
Alta Bates Summit Medical Center-Herrick Campus, Berkeley
Marin General Hospital, Greenbrae
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee
Legacy Mount Hood Medical Center, Gresham
Legacy Good Samaritan Hospital and Medical Center, Portland
PeaceHealth Saint Joseph Medical Center, Bellingham
Legacy Salmon Creek Hospital, Vancouver
Providence Saint Mary Regional Cancer Center, Walla Walla
Stamford Hospital/Bennett Cancer Center, Stamford
MaineHealth Coastal Cancer Treatment Center, Bath
MaineHealth Waldo Hospital, Belfast
MaineHealth Maine Medical Center - Biddeford, Biddeford
Lafayette Family Cancer Center-EMMC, Brewer
MaineHealth Stephens Hospital, Norway
MaineHealth Maine Medical Center - Portland, Portland
Penobscot Bay Medical Center, Rockport
MaineHealth Cancer Care and IV Therapy - Sanford, Sanford
MaineHealth Cancer Care Center of York County, Sanford
MaineHealth Maine Medical Center- Scarborough, Scarborough
MaineHealth Cancer Care and IV Therapy - South Portland, South Portland
Lahey Hospital and Medical Center, Burlington
Lowell General Hospital, Lowell
Las Vegas Cancer Center-Medical Center, Las Vegas
New Hampshire Oncology Hematology PA-Concord, Concord
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Solinsky Center for Cancer Care, Manchester
Virtua Memorial, Mount Holly
Rutgers Cancer Institute of New Jersey, New Brunswick
Sidney Kimmel Cancer Center Washington Township, Sewell
Robert Wood Johnson University Hospital Somerset, Somerville
Atrium Medical Center-Middletown Regional Hospital, Franklin
Penn State Milton S Hershey Medical Center, Hershey
Southwestern Vermont Medical Center, Bennington
Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners
University of Vermont Medical Center, Burlington
University of Vermont and State Agricultural College, Burlington
Dartmouth Cancer Center - North, Saint Johnsbury
Naval Medical Center - Portsmouth, Portsmouth
Arthur J E Child Comprehensive Cancer Centre, Calgary
University Health Network-Princess Margaret Hospital, Toronto
CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal
The Research Institute of the McGill University Health Centre (MUHC), Montreal
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke
Allan Blair Cancer Centre, Regina
Saskatoon Cancer Centre, Saskatoon
Lead Sponsor
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER