PDR001 Plus LAG525 for Patients With Advanced Solid and Hematologic Malignancies

PHASE2CompletedINTERVENTIONAL
Enrollment

76

Participants

Timeline

Start Date

January 24, 2018

Primary Completion Date

February 21, 2019

Study Completion Date

September 17, 2020

Conditions
Small Cell Lung CancerGastric AdenocarcinomaEsophageal AdenocarcinomaCastration Resistant Prostate AdenocarcinomaSoft Tissue SarcomaOvarian AdenocarcinomaAdvanced Well-differentiated Neuroendocrine TumorsDiffuse Large B Cell Lymphoma
Interventions
BIOLOGICAL

PDR001

PDR001 is a high-affinity, ligand-blocking, humanized anti-programmed death-1 (PD-1) IgG4 antibody that blocks the binding of Programmed death-ligand 1 (PD-L1) and programmed death-ligand 2 (PD-L2) to PD-1.

BIOLOGICAL

LAG525

LAG525 is a high-affinity, ligand-blocking, humanized anti-LAG-3 IgG4 antibody which blocks the binding of the known LAG-3 ligand MHC class II to LAG-3.

Trial Locations (20)

30607

University Cancer and Blood Center, LLC, Athens

34952

Hematology Oncology Associates of the Treasure Coast, Port Saint Lucie

46202

Indiana University, Indianapolis

52242

University of Iowa Hospitals and Clinics Comprehensive Cancer Center, Iowa City

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Hospital and Clinics, Madison

59101

Billings Clinic Dept of Billings Clinic(2), Billings

60611

Northwestern University Medical School, Chicago

60612

University of Illinois Cancer Center at Chicago SC, Chicago

66205

The University of Kansas Clinical Research Center, Fairway

68124

Oncology Hematology West Nebraska Cancer Specialists, Omaha

77024

Oncology Consultants Oncology Consultants, Houston

77030

University of Texas - MD Anderson Cancer Center, Houston

89169

Comprehensive Cancer Centers, Las Vegas

97239

Oregon Health and Science University, Portland

98503

Providence Regional Cancer System SC, Lacey

99336

Kadlec Clinic Hematology and Oncology, Kennewick

94120-7999

California Pacific Medical Center Drug Shipment (2), San Francisco

61615-7828

Illinois Cancer Care P.C. Jesse Brown VA, Peoria

21237-3998

Weinberg Cancer Institute at Franklin Square Hospital, Baltimore

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY