GPPAD-POInT (Global Platform of Autoimmune Diabetes - Primary Oral Insulin Trial)

PHASE2CompletedINTERVENTIONAL
Enrollment

1,050

Participants

Timeline

Start Date

February 7, 2018

Primary Completion Date

June 28, 2024

Study Completion Date

June 28, 2024

Conditions
Diabetes Mellitus, Type 1
Interventions
DRUG

Oral Insulin

treatment starting at 4 months - 7 months until age 3.0 years; dose escalation scheme: daily treatment with 7.5 mg or placebo for 2 months; increasing to daily treatment with 22.5 mg or placebo for the following 2 months; increasing to daily treatment with 67.5 mg or placebo until the end of the treatment period.

OTHER

Placebo

treatment starting at age 4 months - 7 months until age 3.0 years; daily treatment with insulin or placebo capsules containing filling substance (microcrystalline cellulose).

Trial Locations (7)

3000

University Hospitals Leuven, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium, Leuven

30173

AUF DER BULT, Kinder- und Jugendkrankenhaus, Hanover, Germany, Hanover

80804

Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Munich, Germany, Munich

01307

Klinik und Poliklinik f. Kinder und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, CRTD/DFG-Forschungszentrum für Regenerative Therapien, Dresden, Germany, Dresden

00-001

Medical University of Warsaw, Department of Paediatrics, Warsaw, Poland, Warsaw

202 13

Lund University Dep. of Clinical Sciences Malmo, Skane University Hospital SUS, University Hospital MAS, Malmo, Sweden, Malmo

OX3 9DU

Department of Paediatrics Clinical Vaccine Research and Immunisation Education, Children's Hospital, Headington, Oxford, UK, Oxford

All Listed Sponsors
collaborator

Helmholtz Zentrum München

INDUSTRY

collaborator

University Hospital Carl Gustav Carus

OTHER

collaborator

Kinderkrankenhaus auf der Bult

OTHER

collaborator

Skane University Hospital

OTHER

collaborator

Universitaire Ziekenhuizen KU Leuven

OTHER

collaborator

Medical University of Warsaw

OTHER

collaborator

University of Oxford, Clinical Vaccine Research and Immunisation Education

UNKNOWN

lead

Technical University of Munich

OTHER

NCT03364868 - GPPAD-POInT (Global Platform of Autoimmune Diabetes - Primary Oral Insulin Trial) | Biotech Hunter | Biotech Hunter