Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL

Administered each cycle on days 1, 3 and 5.

Administered each cycle on days 2, 9, 16 and 23.

Taken orally each cycle on days 2 through 15.

Administered via intramuscular injection (IM) each cycle on days 9 and 23.

Administered via IV each cycle on day 2.

Administered to all subjects via IT injection on day 1; and on days 9, 16, and 23 to CNS positive subjects.

Administered via IT injection to CNS negative subjects on day 16; and to CNS positive subjects on days 9, 16 and 23.

Administered via IT injection to CNS positive subjects on days 9, 16, and 23.