Durvalumab (MEDI4736) in Frail and Elder Patients With Metastatic NSCLC (DURATION)

PHASE2CompletedINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

December 14, 2017

Primary Completion Date

December 31, 2022

Study Completion Date

December 31, 2022

Conditions
Carcinoma, Non-Small-Cell LungMetastatic Lung CancerNon Small Cell Lung CancerLung Adenocarcinoma MetastaticLarge Cell Lung Carcinoma Metastatic
Interventions
DRUG

Durvalumab

Induction: (1125 mg) cycle Q3W Maintenance: (1500 mg) cycle Q4W

DRUG

Vinorelbine

(30 mg/m2 D1 + D8 as infusion) cycle Q3W

DRUG

Gemcitabine

(1000 mg/m2 D1 + D8 as infusion) cycle Q3W

DRUG

nab-Paclitaxel

(100 mg/m2 intravenous infusion over 30 minutes on D1, D8) cycle Q3W

DRUG

Carboplatin

(AUC = 5 mg•min/mL on Day 1) cycle Q3W

Trial Locations (30)

13125

Ev. Lungenklinik Berlin, Berlin

13359

DRK-Kliniken Berlin Mitte, Mitte

17475

Universitätsmedizin Greifswald, Greifswald

26121

Pius Hospital Oldenburg, Oldenburg

33332

Onkodoc GmbH, Gütersloh

48341

"Klinikum Rheine", Rheine

51109

Kliniken der Stadt Köln gGmbH, Cologne

52146

Hämatologisch-Onkologische Praxis Würselen, Würselen

54292

Krankenhaus der Barmherzigen Brüder, Trier

58675

Lungenklinik Hemer, Hemer

60590

Universitätsklinikum Frankfurt, Frankfurt am Main

64283

Klinikum Darmstadt, Darmstadt

66333

SHG-Kliniken-Völklingen, Völklingen

70199

Marienhospital, Stuttgart

70839

Klinik Schillerhöhe, Gerlingen

71640

Klinikum Ludwigsburg, Ludwigsburg

73730

Klinikum Esslingen, Esslingen am Neckar

74245

Klinik Löwenstein gGmbH, Löwenstein

76137

"Vincentius-Diakonissen-Kliniken gAG", Karlsruhe

77933

Ortenau-Klinikum Lahr, Lahr

78052

Schwarzwald-Baar Klinikum, Villingen-Schwenningen

81377

Klinikum der Universität München, München

89081

Universitätsklinikum Ulm, Ulm

92224

Gesundheitszentrum St. Marien GmbH, Amberg

93049

Krankenhaus Barmherzige Brüder, Regensburg

97074

Klinikum Würzburg Mitte gGmbH, Würzburg

01307

Universitätsklinikum Carl-Gustav-Carus, Dresden

06120

Krankenhaus Martha-Maria Halle Dölau, Halle

Unknown

Department of Thoracic Oncology, Thoraxklinik at Heidelberg University Hospital, Heidelberg

04177

Ev. Diakonissenkrankenhaus Leipzig, Leipzig

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

collaborator

Celgene

INDUSTRY

lead

AIO-Studien-gGmbH

OTHER