NCT03344627View on ClinicalTrials.gov

Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients

NACompletedINTERVENTIONAL
Enrollment

76

Participants

Timeline

Start Date

November 27, 2017

Primary Completion Date

November 30, 2018

Study Completion Date

December 31, 2018

Conditions
SepsisSeptic ShockCritical IllnessCarbapenemPharmacokineticPharmacodynamicClinical OutcomeOrgan Failure, MultipleMorality
Interventions
DRUG

Meropenem standard dose

"* Empirical with 1 g meropenem intravenous infusion in 30 minutes then 1 g intravenous infusion in 3 hours every 8 hours.~* Dosage is adjusted in case of renal dysfunction. Duration of therapy is varied regarding source(s) of infection."

DRUG

Meropenem high dose

"* Empirical with 2 g meropenem intravenous infusion in 30 minutes then 2 g intravenous infusion in 3 hours every 8 hours.~* Dosage is adjusted in case of renal dysfunction. Duration of therapy is varied regarding source(s) of infection"

Trial Locations (1)

10400

Faculty of Medicine Ramathibodi Hospital, Ratchathewi

All Listed Sponsors
lead

Mahidol University

OTHER

NCT03344627 - Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients | Biotech Hunter | Biotech Hunter