Secondary Prophylaxis After CMV Disease in Kidney Transplant Patients Targeted by γδ T Cells Immunomonitoring.

PHASE2CompletedINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

November 23, 2017

Primary Completion Date

November 23, 2020

Study Completion Date

November 23, 2020

Conditions
Kidney Transplant Infection
Interventions
DRUG

Group 1_No proph treatment

After the curative treatment of CMV infection until a negative CMV ADNemia, secondary prophylaxis with valganciclovir will be established based on the results of γδ T cells immunomonitoring. In this group, expansion of γδ T cell at the end curative treatment was detected, so secondary prophylaxis will not be started.

DRUG

Group 2A_Proph treatment and γδ T cell expansion

After the curative treatment of CMV infection until a negative CMV ADNemia, secondary prophylaxis with valganciclovir will be established based on the results of γδ T cells immunomonitoring. In this group, γδ T cell expansion will not be detected, so secondary prophylaxis will be initiated in continue during 3 months maximum. The occurrence of γδ T cells expansion during or at the end of secondary prophylaxis will define the group 2A.

DRUG

Group 2B_Proph treatment and no γδ T cell expansion

After the curative treatment of CMV infection until a negative CMV ADNemia, secondary prophylaxis with valganciclovir will be established based on the results of γδ T cells immunomonitoring. In this group, γδ T cell expansion will not be detected, so secondary prophylaxis will be initiated in continue during 3 months maximum. Patients who still not had γδ T cells expansion during or at the end of secondary prophylaxis will compose the group 2B.

Trial Locations (2)

33000

Hôpital Pellegrin - CHU de Bordeaux, Bordeaux

69003

Hôpital Edouard Herriot - Hospices Civils de Lyon, Lyon

All Listed Sponsors
lead

University Hospital, Bordeaux

OTHER

NCT03339661 - Secondary Prophylaxis After CMV Disease in Kidney Transplant Patients Targeted by γδ T Cells Immunomonitoring. | Biotech Hunter | Biotech Hunter