38
Participants
Start Date
November 23, 2017
Primary Completion Date
November 23, 2020
Study Completion Date
November 23, 2020
Group 1_No proph treatment
After the curative treatment of CMV infection until a negative CMV ADNemia, secondary prophylaxis with valganciclovir will be established based on the results of γδ T cells immunomonitoring. In this group, expansion of γδ T cell at the end curative treatment was detected, so secondary prophylaxis will not be started.
Group 2A_Proph treatment and γδ T cell expansion
After the curative treatment of CMV infection until a negative CMV ADNemia, secondary prophylaxis with valganciclovir will be established based on the results of γδ T cells immunomonitoring. In this group, γδ T cell expansion will not be detected, so secondary prophylaxis will be initiated in continue during 3 months maximum. The occurrence of γδ T cells expansion during or at the end of secondary prophylaxis will define the group 2A.
Group 2B_Proph treatment and no γδ T cell expansion
After the curative treatment of CMV infection until a negative CMV ADNemia, secondary prophylaxis with valganciclovir will be established based on the results of γδ T cells immunomonitoring. In this group, γδ T cell expansion will not be detected, so secondary prophylaxis will be initiated in continue during 3 months maximum. Patients who still not had γδ T cells expansion during or at the end of secondary prophylaxis will compose the group 2B.
Hôpital Pellegrin - CHU de Bordeaux, Bordeaux
Hôpital Edouard Herriot - Hospices Civils de Lyon, Lyon
University Hospital, Bordeaux
OTHER