579
Participants
Start Date
January 6, 2018
Primary Completion Date
January 4, 2023
Study Completion Date
January 4, 2023
Ipatasertib
Ipatasertib, 400 milligrams (mg), administered orally once a day (QD) on Days 1-21 of each 28-day cycle until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.
Paclitaxel
Paclitaxel, 80 mg/square meter (m\^2), administered intravenously (IV) on Days 1, 8, and 15 of each 28-day cycle until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.
Placebo
Matching placebo, administered orally QD on Days 1-21 of each 28-day cycle until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.
Oncosalud Sac; Oncología, Lima
National Taiwan Uni Hospital; General Surgery, Taipei
Chi Mei Medical Center Liou Ying Campus, Liuying Township
PHI University Clinic of Radiotherapy and Oncology; Breast malignancy, Skopje
PHI University Clinic of Radiotherapy and Oncology; Malignant diseases of thorax, Skopje
Institute of Oncology Ljubljana, Ljubljana
Orszagos Onkologial Intezet; Onkologiai Osztaly X, Budapest
Cliniques Universitaires St-Luc, Brussels
Chris O'Brien Lifehouse, Camperdown
Westmead Hospital; Medical Oncology, Wentworthville
Medical Oncology Centre of Rosebank; Oncology, Johannesburg
Calvary Mater Newcastle; Medical Oncology, Waratah
UZ Leuven Gasthuisberg, Leuven
Cabrini Medical Centre; Oncology, Malvern
Borsod-Abauj-Zemplen Megyei Korhaz Es Egyetemi Oktato Korhaz; Onkologiai Osztaly, Miskolc
Mater Hospital; Cancer Services, South Brisbane
Hetenyi Geza County Hospital; Onkologiai Kozpont, Szolnok
GHdC Site Notre Dame, Charleroi
Fiona Stanley Hospital; FSH Cancer Centre Clinical Trials Unit, Bull Creek
Szegedi Tudomanyegyetem, AOK, Szent-Gyorgyi Albert Klinikai Kozpont, Onkoterapias Klinika, Szeged
Clinical Hospital; Oncology Department, Bitola
Zala County Hospital ICU, Zalaegerszeg
Dicle Uni Medical Faculty; Internal Medicine, Diyarbakır
Memorial Sloan Kettering, New York
Clinica CIMCA, San José
ICIMED Instituto de Investigación en Ciencias Médicas, San José
National Cancer Center, Goyang-si
Memorial Sloan Kettering Cancer Center at Westchester, Harrison
Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin
Koo Foundation Sun Yat-Sen Cancer Center; Hemato-Oncology, Taipei
Hospital Provincial de Castellon; Servicio de Oncologia, Castellon
Instituto Regional de Enfermedades Neoplasicas - IREN Norte, Trujillo
Hospital Universitario Reina Sofia; Servicio de Oncologia, Córdoba
Clínica San Gabriel; Unidad de Investigación Oncológica de la Clínica San Gabriel, Lima
Hospital Nacional Cayetano Heredia; Ocología; Servicio de Hematología Oncología Médica, Lima
Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia, Santiago de Compostela
Universitätsfrauen- und Poliklinik am Klinikum Suedstadt, Rostock
Hospital de Donostia; Servicio de Oncologia, Guipuzcoa
Universitätsklinikum Hamburg-Eppendorf; Frauenklinik, Hamburg
Centre Georges Francois Leclerc; Oncologie 3, Dijon
University of Maryland, Baltimore
Mercy Medical Center, Baltimore
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore
Inha University Hospital, Incheon
CHU Besançon - Hôpital Jean Minjoz, Besançon
Hospital Ramon y Cajal; Servicio de Oncologia, Madrid
HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia, Madrid
Hospital Universitario Puerta de Hierro; Servicio de Oncologia, Majadahonda
Mühlenkreiskliniken; Johannes Wesling Klinikum Minden; Klinik für Frauenheilkunde und Geburtshilfe, Minden
UF Health Cancer Center at Orlando Health, Orlando
Memorial Regional Hospital, Hollywood
Memorial Hospital West, Pembroke Pines
Irccs Centro Di Riferimento Oncologico (CRO); Dipartimento Di Oncologia Medica, Aviano
Mount Sinai Comprehensive Cancer Center, Miami Beach
Polyclinique Bordeaux Nord Aquitaine, Bordeaux
Medipol University Medical Faculty; Oncology Department, Istanbul
ICM; Medecine B3, Montpellier
Prof. Dr. Cemil Tascioglu City Hospital; Med Onc, Istanbul
IOV - Istituto Oncologico Veneto - IRCCS; Oncologia Medica II, Padua
Katip Celebi University Ataturk Training and Research Hospital; Oncology, Izmir
National Cancer Institute MOH of Ukraine, Kiev
West Clinic, Germantown
Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica, Bologna
Hospital Universitario Virgen del Rocio; Servicio de Oncologia, Seville
Centre Catherine De Sienne, Nantes
Oncologianova GmbH - Gesellschaft für Innovationen in der Onkologie, Recklinghausen
Hospital Clinico Universitario; Oncologia, Valencia
Chemotherapy SI Dnipropetrovsk MA of MOHU, Dnipropetrovsk
Ospedale Santa Maria Annunziata; Oncologia, Bagno a Ripoli
Praxis Dr.med. Katja Ziegler-Löhr, Cologne
Institut Jean Godinot; Oncologie Medicale, Reims
Sakarya University Medical School; Medical Oncology, Sakarya
Dres. Andreas Köhler und Roswitha Fuchs, Langen
Centro Médico Zambrano Hellion, Monterrey
Universitätsklinikum des Saarlandes; Klinik f. Frauenheilkunden und Geburtshilfe, Homburg/Saar
Texas Oncology, P.A., Dallas
UT Southwestern Medical Center; Simmons Comprehensive Cancer Center, Simmons Pharmacy, Dallas
APHP - Hospital Saint Louis, Paris
Oncology Consultants PA, Houston
Lviv State Oncological Regional Treatment and Diagnostic Center, Lviv
Praxis für Interdisziplinäre Onkologie und Hämatologie GbR, Freiburg im Breisgau
Istituto Nazionale Tumori Irccs Fondazione g. PASCALE;U.O.C. Oncologia Medica Senologica, Napoli
USC Norris Cancer Center, Los Angeles
UCSD Moores Cancer Center, La Jolla
USC Norris Cancer Center; USC Oncology Hematology Newport Beach, Newport Beach
Kaiser Permanente - South San Francisco, South San Francisco
Kaiser Permanente - San Francisco (2238 Geary), San Francisco
UCSF Comprehensive Cancer Ctr, San Francisco
Kaiser Permanente - San Leandro, San Leandro
Kaiser Permanente - Vallejo, Vallejo
K. Permanente - Walnut Creek, Walnut Creek
Kaiser Permanente - Oakland, Oakland
K. Permanente - Santa Clara, Santa Clara
K. Permanente - San Jose, San Jose
Kaiser Permanente - Roseville, Roseville
UC Davis; Comprehensive Cancer Center, Sacramento
Kaiser Permanente Sacramento Medical Center, Sacramento
Universitätsklinikum Würzburg; Frauenklinik, Würzburg
Indraprastha Apollo Hospitals, New Delhi
Rajiv Gandhi Cancer Inst.&Research Center; Medical Oncology, New Delhi
Blokhin Cancer Research Center; Combined Treatment, Moskva
National University Hospital; National University Cancer Institute, Singapore (NCIS), Singapore
Federal State Institution, Moscow Research Oncology Institute n.a. P.A. Hertzen; Oncourology, Moscow
Moscow City Oncology Hospital #62, Moscovskaya Oblast
Ivanovo Regional Oncology Dispensary, Ivanovo
Arkhangelsk Regional Clinical Oncology Dispensary, Arkhangelsk
National Cancer Centre; Medical Oncology, Singapore
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological), Saint Petersburg
SBIH Kaluga Region Clinical Oncology Dispensary, Kaluga
FSI Rostov research oncological institute of MoH and SD of RF; PAD, Rostov-on-Don
Clinical Oncology Dispensary of Ministry of Health of Tatarstan, Kazan'
Sociedad de Investigaciones Medicas Ltda (SIM), Temuco
Fundación CENIT para la Investigación en Neurociencias, Buenos Aires
Hosp Provincial D. Centenarios; Oncology Dept, Rosario
Santa Casa de Misericordia de Salvador, Salvador
Hospital Araujo Jorge; Departamento de Ginecologia E Mama, Goiânia
Hospital do Câncer de Londrina, Londrina
Instituto Nacional de Cancer - INCa; Oncologia, Rio de Janeiro
Hospital Sao Lucas - PUCRS, Porto Alegre
Hospital Nossa Senhora da Conceicao, Porto Alegre
Faculdade de Medicina do ABC - FMABC, Santo André
Hospital Perola Byington, São Paulo
British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre, Vancouver
Jewish General Hospital, Montreal
Masaryk?v onkologický ústav; Klinika komplexní onkologické pé?e, Brno
Fakultni nemocnice Olomouc; Onkologicka klinika, Olomouc
Anticancer Hospital Ag Savas; 1St Dept of Internal Medicine, Athens
Agioi Anargyroi; 3Rd Dept. of Medical Oncology, Athens
Euromedical General Clinic of Thessaloniki; Oncology Department, Thessaloniki
Aichi Cancer Center Hospital, Aichi
National Cancer Center Hospital East, Chiba
National Hospital Organization Kyushu Cancer Center;Breast Oncology, Fukuoka
Fukushima Medical University Hospital, Fukushima
Hyogo Medical University Hospital, Hyōgo
St. Marianna University Hospital, Kanagawa
Kanagawa Cancer Center, Kanagawa
Tokai University Hospital, Kanagawa
Kumamoto Shinto General Hospital, Kumamoto
Niigata Cancer Center Hospital, Niigata
Okayama University Hospital, Okayama
National Hospital Organization Osaka National Hospital, Osaka
Kinki University Hospital, Faculty of Medicine; Surgery, Osaka
Saitama Cancer Center, Breast Oncology, Saitama
Shizuoka Cancer Center, Shizuoka
National Cancer Center Hospital, Tokyo
St. Luke's International Hospital, Tokyo
The Cancer Institute Hospital of JFCR, Tokyo
Showa University Hospital; Breast Surgery, Tokyo
Centro Medico Dalinde, Mexico City
"Merida , Investigacion Clinica"
CENEIT Oncologicos; DENTRO DE CONDOMINIO SAN FRANCISCO, Mexico City
Centro Medico Monte Carmelo, Arequipa
Hospital Daniel Alcides Carrion, Callao
Instituto Nacional de Enfermedades Neoplasicas, Lima
Clinica Ricardo Palma, San Isidro
Instyt. Centrum Zdrowia Matki Polki; Klinika Chirurgii Onk. Chorób Piersi z Podod. Onko Klinicznej, ?ód?
Narodowy Inst.Onkol.im.Sklodowskiej-Curie Panstw.Inst.Bad Gliwice; III Klin. Radioter. i Chemioter., Gliwice
Narodowy Instytut Onkologii im. M.Sklodowskiej-Curie; Klinika Nowotworow Piersi i Chirurgii Rekonstr, Warsaw
Seoul National University Bundang Hospital, Seongnam-si
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Hospital del Mar; Servicio de Oncologia, Barcelona
Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona
Hospital Clinic Barcelona; Servicio de oncologia, Barcelona
VETERANS GENERAL HOSPITAL; Department of General Surgery, Taipei
Ankara Bilkent City Hospital, Ankara
Kyiv City Clinical Oncological Center, Day Hospital Department for Oncological patients, Kiev
Velindre Cancer Centre, Cardiff
University Hospital coventry; Oncology Department, Coventry
The Beatson West of Scotland Cancer Centre; Cancer Clinical Trials Unit, Glasgow
Royal Marsden Hospital - London, London
Derriford Hospital, Plymouth
Royal Stoke University Hospital, Stoke-on-Trent
Royal Marsden Hospital; Dept of Medical Oncology, Sutton
Hoffmann-La Roche
INDUSTRY