590
Participants
Start Date
October 31, 2017
Primary Completion Date
May 7, 2021
Study Completion Date
September 30, 2026
Zanubrutinib
Administered as two 80-milligram (mg) capsules by mouth twice a day (160 mg twice a day)
Bendamustine
Administered intravenously (IV) at a dose of 90 mg/m\^2/day on the first 2 days of each cycle for 6 cycles.
Rituximab
Administered intravenously (IV) at a dose of 375 mg/m\^2 on day 0 of cycle 1, and at a dose of 500 mg/m\^2 on day 1 of cycles 2 to 6
Venetoclax
400 mg tablets administered orally once daily.
Hualien Tzu Chi Hospital, Hualien City
Auckland City Hospital, Auckland
Universitair Ziekenhuis Brussel, Brussels
Clinique Saint Pierre, Ottignies
Concord Repatriation General Hospital, Concord
Westmead Hospital, Westmead
Calvary Mater Newcastle, Waratah
The Tweed Valley Hospital, Cudgen
Peter Maccallum Cancer Centre, Melbourne
St Vincents Hospital Melbourne, Fitzroy
Tauranga Hospital, Tauranga
Box Hill Hospital, Box Hill
Monash Health, Clayton
Peninsula Private Hospital, Frankston
Centre Hospitalier Universitaire (Chu) de Liege Site Du Sart Tilman, Liège
Krankenhaus Der Barmherzigen Schwestern Linz, Linz
Allgemeines Krankenhaus Der Stadt Linz, Linz
Royal Brisbane and Womens Hospital, Herston
Icon Cancer Centre Wesley, Auchenflower
Princess Alexandra Hospital, Brisbane
Palmerston North Hospital, Palmerston North
Klinikum Wels Grieskirchen, Wels
Royal Adelaide Hospital, Adelaide
The Queen Elizabeth Hospital, Woodville South
Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg, Salzburg
Centre Hospitalier Universitaire Universite Catholique de Louvain Site Godinne, Yvoir
Royal Perth Hospital, Perth
Medizinische Universitatsklinik Innsbruck, Innsbruck
Royal Hobart Hospital, Hobart
Christchurch Hospital, Christchurch
Universitair Ziekenhuis Gent, Ghent
Vseobecna Fakultni Nemocnice V Praze, Prague
Icahn School of Medicine At Mount Sinai, New York
Columbia University Medical Center, New York
Ao Citta Della Salute E Della Scienza Di Torino Presidio O, Torino
Institut Paoli Calmettes, Marseille
Chu Caen Normandie, Caen
University of Rochester, Rochester
Fondazione Irccs Ca Granda Ospedale Maggiore Policlinico, Milan
Ospedale San Raffaele, Milan
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan
University of Virginia, Charlottesville
Taipei Medical University Shuang Ho Hospital, New Taipei City
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia, Brescia
Duke University, Durham
Hospital de La Princesa, Madrid
Clinica Universidad de Navarra, Madrid
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda
Augusta University, Augusta
Clinica Universidad de Navarra Pamplona, Pamplona
Centre de Lutte Contre Le Cancer Institut Bergonie, Bordeaux
Groupe Hospitalier Du Haut Leveque, Pessac
Hopital Pontchaillou, Rennes
Chu Tours Hopital Bretonneau Service Pneumologie, Tours
Tennessee Oncology, Pllc Nashville, Nashville
Universita Degli Studi Di Modena Azienda Ospedaliere Policlinco, Modena
Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes
Hospital Universitari I Politecnic La Fe, Valencia
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst, Meldola
Azienda Unita Sanitaria Locale Di Ravenna, Ravenna
Fakultni Nemocnice Hradec Kralove, Hradec Králové
Hospital de Dia Quironsalud Zaragoza, Zaragoza
Hopital Robert Debre, Reims
Chu Nancy Hopital Brabois, VandoeuvrelesNancy
Prairie Lakes Healthcare System, Watertown
Northwestern University, Chicago
Fakultni Nemocnice Brno, Brno
Washington University, St Louis
Research Medical Center, Kansas City
Chu Hopital Lyon Sud, PierreBenite
Centre Hospitalier Le Mans, Le Mans
Hopital de La Pitie Salpetriere, Paris
Uppsala Akademiska Sjukhus, Uppsala
Centre Henri Becquerel, Rouen
Fakultni Nemocnice Olomouc, Olomouc
Joe Arrington Cancer Research and Treatment Center, Lubbock
Centre Hospitalier Departemental de Vendee, La Roche-sur-Yon
Centre Hospitalier Universitaire de Poitier Hopital de La Miletrie Hopital Jean Bernard, Poitiers
Centre Hospitalier Universitaire Limoges Chu de Limoges, Limoges
Comprehensive Cancer Centers of Nevada, Las Vegas
Centre Hospitalier Victor Dupouy Dargenteuil, Argenteuil
Oregon Health and Science University, Portland
Va Puget Sound Health Care System, Seattle
Fred Hutchinson Cancer Research Center, Seattle
Peking University Third Hospital, Beijing
Beijing Friendship Hospital, Capital Medical University, Beijing
National Taiwan University Hospital East Campus, Taipei
Peking Union Medical College Hospital, Beijing
N N Blokhin Russian Cancer Research Center Konstantin Laktionov, Moscow
Russian Academy of Advanced Medical Studies, City Clinical Hospital, Moscow
The First Hospital of Jilin University, Changchun
Fgu Russian Scientific Research Institute of Hematology and Transfusiology, Saint Petersburg
Jiangsu Province Hospital, Nanjing
Wuxi Peoples Hospital, Wuxi
The First Affiliated Hospital of Soochow University Branch Shizi, Suzhou
Anhui Provincial Hospital, Hefei
Kaluga Regional Hospital, Kaluga
Institute of Hematology and Hospital of Blood Disease, Tianjin
Tula Area Clinical Hospital, Tula
Tianjin Medical University Cancer Institute and Hospital, Tianjin
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou
The First Affiliated Hospital of Nanchang University Branch Donghu, Nanchang
Fujian Medical University Union Hospital, Fuzhou
State Healthcare Institution Oncologic Dispensary No Health Department of Krasnodar Region, Sochi
Quanzhou First Affliated Hospital of Fujian Medical University, Quanzhou
Ryazan Regional Clinical Hospital, Ryazan
Second Affiliated Hospital of Army Medical University (Xinqiao Hospital), Chongqing
State Budgetary Healthcare Institution Volgograd Regional Clinical Oncology Dispensary, Volgograd
Clinical Oncology Dispensary, Kazan
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
State Budgetary Healthcare Institution Regional Clinical Dispensary, Penza
Henan Cancer Hospital, Zhengzhou
Guangdong Provincial Peoples Hospital, Guangzhou
Nizhniy Novgorod Regional Clinical Hospital Nasemashko, Nizhny Novgorod
West China Hospital, Sichuan University, Chengdu
State Budgetary Healthcare Institution of Perm Krai Clinical Medical Sanitary Establishment, Perm
Sverdlovsk Regional Clinical Hospital, Yekaterinburg
Central City Hospital, Yekaterinburg
Kemerovo Regional Clinical Hospital Na Sv Belyaev, Kemerovo
Dana Farber Cancer Institute, Boston
Summit Medical Group, Florham Park
Universita Degli Studi La Sapienza, Roma
Fondazione Policlinico Universitario Agostino Gemelli, Roma
Azienda Ospedaliera S Maria Di Terni, Terni
North Shore Hospital, Takapuna
Szpital Specjalist W Brzozowie,Podkarpacki Osrodek Onkologiczny, Brzozów
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich, Chorzów
Copernicus Podmiot Leczniczy Sp Z Oo Wojewodzkie Centrum Onkologii, Gdansk
Szpitale Pomorskie Spolka Z Ograniczona Odpowiedzialnoscia, Gdynia
Centrum Onkologii Instytut Im Marii Sklodowskiej Curie, Oddzial W Gliwicach, Gliwice
Malopolskie Centrum Medyczne Sc, Krakow
Wojewodzki Szpital Specjalistyczny W Legnicy, Legnica
Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz
Centrum Onkologii Ziemi Lubelskiej, Lublin
Hospital Universitari Germans Trias I Pujol, Badalona
Hospital Del Mar, Barcelona
Institut Catala Doncologia, Barcelona
Medicinkliniken, Borås
Sahlgrenska Universitetssjukhuset, Gothenburg
Skanes Universitetssjukhus I Lund, Lund
Universitetssjukhuset Orebro, Örebro
Karolinska Universitetssjukhuset Solna, Stockholm
Birmingham Heartlands Hospital, Birmingham
The Royal Bournemouth and Christchurch Hospitals Nhs Foundation, Bournemouth
Cambridge University Hospitals Nhs Foundation Trust, Cambridge
Kent and Canterbury Hospital, Canterbury
The Christie Hospital, Greater Manchester
The Leeds Teaching Hospitals Nhs Trust, Leeds
Barts and the London Nhs Trust, London
Royal Marsden Hospital, London
Sarah Cannon Research Institute Uk, London
Maidstone and Tunbridge Wells Nhs Trust, Kent Oncology Centre, Maidstone Hospital, Maidstone
Norfolk and Norwich University Hospitals Nhs Foundation Trust, Norwich
Nottingham University Hospitals Nhs Trust, Nottingham
Derriford Hospital, Plymouth
Southampton General Hospital, Southampton
Sunderland Royal Hospital, Sunderland
The Royal Wolverhampton Nhs Trust, Wolverhampton
Lead Sponsor
BeiGene
INDUSTRY