14
Participants
Start Date
January 1, 2018
Primary Completion Date
August 1, 2019
Study Completion Date
August 1, 2019
Hyperoxic Hypercapnic Ventilatory Response Test
End-tidal PO2 will be clamped at 300 mmHg while end-tidal PCO2 will be increased in three minutes stages from baseline to +2, +4, and +6 mmHg.
Hypoxic Hypercapnic Ventilatory Response Test
End-tidal PO2 will be clamped at normoxic levels while end-tidal PCO2 will be increased in three minutes stages from baseline to +2, +4, and +6 mmHg.
Repeated Hypoxic Apneas
Six hypoxic apnea cycles will be performed. One apneic cycle involves breathing 2-3 breaths of 100% Nitrogen and breath-holding for 20s followed by room air breathing.
Hypoxic Sleep Study
Participants will be instrumented with a sleep monitoring system and will sleep in a normobaric hypoxic chamber with a fraction of inspired oxygen of 13.5%.
Losartan
Losartan, 50mg, BID
Placebo
Placebo, 50mg, BID
University of British Columbia, Kelowna
University of British Columbia
OTHER