8
Participants
Start Date
July 24, 2018
Primary Completion Date
June 29, 2023
Study Completion Date
June 29, 2023
Everolimus
Given once daily orally via mouth or NG tube beginning at Dose Level (DL) 1 (4 mg/m2/day). Depending on safety and tolerability, dose levels will be escalated to DL2 (5 mg/m2/day). There is also a dose level de-escalation to DL0 (3 mg/m2/day) if toxicity is noted at DL1. Begins at Day 1 through 28.
Nelarabine
650 mg/m2 IV daily x Day 1-5
Cyclophosphamide
440 mg/m2 IV x Day 1-5
Etoposide
100 mg/m2 IV x Day 1-5
Memorial Sloan Kettering Cancer Center, New York
Children's Healthcare of Atlanta, Atlanta
Cincinnati Children's Hospital, Cincinnati
Texas Children's Hospital, Houston
Emory University
OTHER