Regenerative Endodontic Therapy (RET) for the Management of Immature Non-vital Permanent Teeth in Children

PHASE2CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

March 1, 2017

Primary Completion Date

July 31, 2021

Study Completion Date

July 31, 2021

Conditions
Infected Immature Permanent Teeth
Interventions
DRUG

RET using antibiotics (Ciprofloxacin and Metronidazole)

RET using antibiotics Ciprofloxacin and Metronidazole. First Treatment Visit: Local analgesic, tooth isolation, access, pulp extirpation and root canal irrigation with 1.5% sodium hypochlorite. Canal drying using paper points. Delivery of mixture of Bi antibiotic paste (Ciprofloxacin and Metronidazole with sterile water). Tooth access sealed with temporary dressing. Second Treatment Visit: Tooth analgesia using plain local analgesics without vasoconstriction, isolation and re-access as described above. Irrigation of root canal system using sodium hypochlorite followed by paper point drying. Initiation of bleeding through insertion of a sterile k-file at a length of 2-3 mm beyond the working length into the periapical tissues. Access sealed using resorbable plug, Biodentine, followed by composite resin.

DRUG

RET using non-setting Calcium Hydroxide

First Treatment Visit: Local analgesic, Tooth isolation, access, pulp extirpation and root canal irrigation with 1.5% sodium hypochlorite. Canal negotiation, canal drying using paper points. Delivery of the non-setting Calcium Hydroxide. Tooth access sealed with temporary dressing. Second Treatment Visit: Tooth analgesia using plain local analgesics without vasoconstrictor, isolation and re-access as described above. Irrigation of root canal system using sodium hypochlorite followed by paper point drying. Initiation of bleeding through insertion of a sterile k-file at a length of 2-3 mm beyond the working length into the periapical tissues. Access sealed using resorbable plug, Biodentine, followed by composite resin.

Trial Locations (2)

168937

School Dental Service, Health Promotion Board, Singapore

Unknown

National University Hospital, Singapore

All Listed Sponsors
collaborator

National University of Singapore

OTHER

collaborator

Health Promotion Board, Singapore

OTHER_GOV

lead

National University Health System, Singapore

OTHER

NCT03327844 - Regenerative Endodontic Therapy (RET) for the Management of Immature Non-vital Permanent Teeth in Children | Biotech Hunter | Biotech Hunter