105
Participants
Start Date
December 12, 2017
Primary Completion Date
December 24, 2020
Study Completion Date
July 12, 2024
Niraparib
Niraparib will be administered orally once a day continuously throughout each 21 day cycle (84-day cycle after amendment 2). The starting dose of niraparib will be based on the participant's Baseline actual body weight or platelet count. Participants with a Baseline actual body weight of greater than equal to (\>=) 77 kg and Baseline platelet count of \>=150,000/ microliter (μL) will take 300 mg/day (3X100mg) at each dose administration. Participants with a Baseline actual body weight of less than (\<) 77 kg and/or Baseline platelet count of \<150,000/μL will take 200 mg (2X100 mg) at each dose administration.
Bevacizumab
Maintenance bevacizumab 15 mg/kg will be administered via a 30-minute IV infusion on Day 1 of every 21-day cycle in the absence of progressive disease (PD), unacceptable toxicity, participant withdrawal, Investigator's decision, or death. Bevacizumab will be administered for up to 10 months during the maintenance phase or up to a total of 15 months inclusive of approximately 5 months of bevacizumab received with chemotherapy.
GSK Investigational Site, Albany
GSK Investigational Site, Rochester
GSK Investigational Site, Pittsburgh
GSK Investigational Site, Asheville
GSK Investigational Site, St. Petersburg
GSK Investigational Site, Fort Myers
GSK Investigational Site, Mobile
GSK Investigational Site, Nashville
GSK Investigational Site, Chattanooga
GSK Investigational Site, Kingsport
GSK Investigational Site, Jackson
GSK Investigational Site, Columbus
GSK Investigational Site, Detroit
GSK Investigational Site, Detroit
GSK Investigational Site, Kansas City
GSK Investigational Site, Columbia
GSK Investigational Site, Kansas City
GSK Investigational Site, Oklahoma City
GSK Investigational Site, Fort Worth
GSK Investigational Site, Mesa
GSK Investigational Site, Los Angeles
GSK Investigational Site, Burbank
GSK Investigational Site, Seattle
GSK Investigational Site, Anchorage
GSK Investigational Site, Lebanon
GSK Investigational Site, Englewood
GSK Investigational Site, Morristown
GSK Investigational Site, Summit
GSK Investigational Site, Providence
Tesaro, Inc.
INDUSTRY