233
Participants
Start Date
January 9, 2018
Primary Completion Date
December 13, 2018
Study Completion Date
October 16, 2020
Pembrolizumab
Pembrolizumab administered intravenously every 3 weeks.
Epacadostat
Epacadostat administered orally twice daily.
Platinum-based chemotherapy
Investigator selected one of the following regimens: pemetrexed + cisplatin, pemetrexed + carboplatin, or paclitaxel + carboplatin, depending on histology.
Placebo
Matching placebo administered orally twice daily.
Chang Gung Medical Foundation, Kaohsiung Branch, Kaohsiung City
Orszagos Koranyi TBC es Pulmonologiai Intezet, Budapest
Chris OBrien Lifehouse, Camperdown
The Crown Princess Mary Cancer Centre Westmead, Westmead
Blacktown Hospital, Blacktown
MNCCI Port Macquarie Base Hospital, Port Macquarie
Southern Medical Day Care Centre, Wollongong
CRU Hungary Kft., Miskolc
Cairns Base Hospital, Cairns
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet, Szolnok
Bekes Megyei Pandy Kalman Korhaz, Gyula
Veszprem Megyei Tudogyogyintezet, Farkasgyepű
Zala Megyei Korhaz Pozvai Telephely, Pózva
National Taiwan University Hospital, Taipei
National Cancer Center, Goyang-si
New York Oncology Hematology P.C, Albany
Allegheny General Hospital, Pittsburgh
Uludag Universitesi Tip Fakultesi, Bursa
St. Luke's Hospital - Anderson Campus, Easton
Pamukkale Unv. Tip Fak, Denizli
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Istituto Europeo di Oncologia, Milan
Ospedale San Gerardo - ASST Monza, Monza
Hospital Juan Ramón Jimenez, Huelva
Emily Couric Clinical Cancer Center, Charlottesville
Oncology & Hematology Assoc. SW Virginia, Inc., DBA Blue Ridge Cancer Care, Blacksburg
Hospital Universitario La Paz, Madrid
Centro Di Riferimento Oncologico, Aviano
Chang Gung Medical Foundation, Linkou Branch, Taoyuan District
Lynn Cancer Institute, Boca Raton
Florida Cancer Specialists (North Region), St. Petersburg
Istanbul Universitesi Cerrahpasa Tip Fakultesi, Istanbul
Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria
Ege Universitesi Tip Fakultesi Hastanesi, Izmir
Southern Cancer Center, PC, Daphne
Tennessee Oncology, PLLC/The Sarah Cannon Research Institute, Nashville
Tennessee Oncology, PLLC/The Sarah Cannon Research Institute, Chattanooga
China Medical University Hospital, Taichung
Oncology Hematology Care, Inc., Cincinnati
Hospital Universitario La Fe, Valencia
PPG-Oncology, Fort Wayne
University of Michigan, Ann Arbor
Hospital Clinico Universitario Lozano Blesa, Zaragoza
Chaim Sheba Medcal Center, Ramat Gan
Samsun Medical Park Hastanesi, Samsun
MMCORC, Saint Louis Park
Namık Kemal University Medical Faculty, Tekirdağ
St. Vincent Healthcare Frontier Cancer Center, Billings
Oaxaca Site Management Organization S.C., Oaxaca City
National Cheng Kung University Hospital, Tainan City
Southwestern Regional Medical Center, Inc., Tulsa
Texas Oncology-Denton South, Denton
Western Regional Medical Center, Inc., Goodyear
Arizona Oncology Associates PC- HOPE, Tucson
FAICIC Clinical Research, Veracruz
A.O.U. Policlinico Vittorio Emanuele - Presidio Gaspare Rodolico, Catania
Medical Care Research S.A. de C.V., Mérida
Seattle Cancer Care Alliance, Seattle
Central Clinical Hospital with polyclinic, Moscow
Moscow Research Oncology Institute, Moscow
SBHI Leningrad Regional Clinical Hospital, Saint Petersburg
Belgorod Regional Oncology Dispensary, Belgorod
Oncological Dispensary #2 of Ministry of Health of Krasnodar region, Sochi
SBI of Stavropol region Pyatigorskiy Oncologic dispensary, Pyatigorsk
Republican Clinical Oncology Dispensary of Tatarstan MoH, Kazan'
Udmurtia Republic Regional Clinical Oncology Dispensary, Izhevsk
SBHI Samara Regional Clinical Oncology Dispensary, Samara
Tomsk Scientific Research Institute of Oncology, Tomsk
Ha Emek Medical Center, Afula
Rambam Medical Center, Haifa
Meir Medical Center, Kfar Saba
Rabin Medical Center, Petah Tikva
Soroka Medical Center, Beersheba
Florida Cancer Specialists (South Region), Fort Myers
BCCA-Cancer Centre of the Southern Interior, Kelowna
Lions Gate Hospital, North Vancouver
CISSS de la Monteregie-Centre, Greenfield Park
CSSS de Laval- Hopital de la Cite de la Sante, Laval
CIUSSS Ouest de l'Ile - St-Mary's Hospital, Montreal
CIUSSS du Nord-de-l'ILe-de-Montreal Hopital du Sacre-Coeur de Montreal, Montreal
CHU de Quebec - Hotel-Dieu de Quebec, Québec
CIUSSS de la Mauricie-et-du-Centre-du-Quebec, Trois-Rivières
St Vincents University Hospital, Dublin
Severance Hospital Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Institut Catala Oncologia de Bellvitge - ICO, L'Hospitalet de Llobregat
Baskent Universitesi Adana Uygulama ve Arastirma Hastanesi, Adana
Cukurova Universitesi Tıp Fakultesi Balcalı Hastanesi, Adana
Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara
Mount Vernon Cancer Centre, Northwood
Western General Hospital, Edinburgh
North Middlesex Hospital, London
Freeman Hospital Newcastle upon Tyne Foundation NHS Trust, Newcastle upon Tyne
Lead Sponsor
Merck Sharp & Dohme LLC
INDUSTRY
Incyte Corporation
INDUSTRY