Pembrolizumab Plus Epacadostat vs Pembrolizumab Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-654-05/ECHO-305-05)

PHASE2CompletedINTERVENTIONAL
Enrollment

154

Participants

Timeline

Start Date

December 15, 2017

Primary Completion Date

January 10, 2019

Study Completion Date

November 9, 2020

Conditions
Lung Cancer
Interventions
DRUG

Pembrolizumab

Pembrolizumab administered intravenously every 3 weeks.

DRUG

Epacadostat

Epacadostat administered orally twice daily.

DRUG

Placebo

Matching placebo administered orally twice daily.

Trial Locations (101)

1211

Hopitaux Universitaires de Geneve HUG., Geneva

2100

Rigshospitalet, Copenhagen

3010

Inselspital Universitatsspital Bern, Bern

3084

Austin Health-Austin Hospital, Heidelberg

5000

Odense Universitetshospital, Odense

6150

St John of God Murdoch Medical Clinic, Murdoch

6500

Oncological Institute of Southern Switzerland, Bellinzona

7400

Regionshospitalet Herning, Herning

8003

Hospital del Mar, Barcelona

8091

Universitaetsspital Zuerich, Zurich

8401

Kantonsspital Winterthur, Winterthur

13620

Seoul National University Bundang Hospital, Seongnam-si

15224

Allegheny General Hospital, Pittsburgh

16132

IRCCS A.O.U. San Martino - IST, Genova

20850

Maryland Oncology Hematology, P.A., Rockville

21237

Weinberg Cancer Institute at Franklin Square, Baltimore

21401

Anne Arundel Health System Research Institute, Annapolis

21565

Gacheon University Gil Medical Center, Incheon

25001

PP PPC Acinus Medical and Diagnostic Centre, Kirovohrad

25100

Hospital Tengku Ampuan Afzan, Kuantan

28040

Hospital Clinico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

30265

Southeastern Regional Medical Center, Inc., Newnan

31096

Rambam Medical Center, Haifa

33705

Florida Cancer Specialists (North Region), St. Petersburg

33916

Florida Cancer Specialists (South Region), Fort Myers

36312

Hospital Alvaro Cunqueiro, Vigo

37203

Tennessee Oncology, PLLC/The Sarah Cannon Research Institute, Nashville

37404

Tennessee Oncology, PLLC/The Sarah Cannon Research Institute, Chattanooga

38039

Erciyes Universitesi Tip Fakultesi, Kayseri

41009

Hospital Universitario Virgen Macarena, Seville

42080

Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi, Konya

43018

Volyn Regional Oncological Dispensary, Lutsk

46010

Hospital Clinico de Valencia, Valencia

49102

Dnipropetrovsk City Multidiscipline Clinical Hosp.4 of DRC, Dnipropetrovsk

50048

MI Kryviy Rih Center of Dnipropetrovsk Regional Council, Kryvyi Rih

51014

SA Tartu Ulikooli Kliinikum, Tartu

52621

Chaim Sheba Medical Center, Ramat Gan

55433

Minnesota Oncology Hematology, PA, Coon Rapids

59100

University Malaya Medical Centre, Kuala Lumpur

61024

Grigoriev Institute for medical Radiology NAMS of Ukraine, Kharkiv

62250

Institut Kanser Negara - National Cancer Institute, Putrajaya

65055

MI Odessa Regional Oncological Centre, Odesa

68130

Nebraska Cancer Specialists, Omaha

69040

Zaporizhzhya Regional Clinical Oncology Center, Zaporizhzhya

78745

Texas Oncology-South Austin, Austin

90603

Innovative Clinical Research Institute, Whittier

92801

Pacific Cancer Medical Center, Inc., Anaheim

121359

Central Clinical Hospital with polyclinic, Moscow

125284

Moscow Research Oncology Institute named after P.A. Hertsen, Moscow

194291

SBHI Leningrad Regional Clinical Hospital, Saint Petersburg

308010

Belgorod Regional Oncology Dispensary, Belgorod

443031

SBHI Samara Regional Clinical Oncology Dispensary, Samara

450054

Republican Clinical Oncology Dispensary of Republic of Bashkortostan, Ufa

4428164

Meir Medical Center, Kfar Saba

4941492

Rabin Medical Center, Petah Tikva

8457108

Soroka Medical Center, Beersheba

01655

UMass Memorial Medical Center, Worcester

T6G 1Z2

Cross Cancer Institute, Edmonton

E1C 6Z8

Moncton Hospital - Horizon Health Network, Moncton

L6R 3J7

William Osler Health System, Brampton

K7L 2V7

Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston

P6B 0A8

Sault Area Hospital, Sault Ste. Marie

H91 YR71

Galway University Hospital, Galway

Dublin 4

St Vincents University Hospital, Dublin

00168

Policlinico Universitario Agostino Gemelli, Roma

460-0001

National Hospital Organization Nagoya Medical Center, Nagoya

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

830-0011

Kurume University Hospital, Kurume

920-8641

Kanazawa University Hospital, Kanazawa

241-8515

Kanagawa Cancer Center, Yokohama

980-0873

Sendai Kousei Hospital, Sendai

573-1191

Kansai Medical University Hospital, Hirakata

589-8511

Kindai University Hospital, Sayama

411-8777

Shizuoka Cancer Center, Nagaizumi-chō

811-1395

National Hospital Organization Kyushu Cancer Center, Fukuoka

812-8582

Kyushu University Hospital, Fukuoka

951-8566

Niigata Cancer Center Hospital, Niigata

700-8558

Okayama University Hospital, Okayama

104-0045

National Cancer Center Hospital, Tokyo

113-8603

Nippon Medical School Hospital, Tokyo

135-8550

The Cancer Institute Hospital of JFCR, Tokyo

641-8509

Wakayama Medical University Hospital, Wakayama

Unknown

Pantai Hospital Kuala Lumpur, Kuala Lumpur

Sarawak General Hospital, Kuching

85-796

Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz

44-101

Centrum Onkologii. Instytut im. Marii Sklodowskiej-Curie, Gliwice

25-734

Swietokrzyskie Centrum Onkologii SPZOZ, Kielce

Swietokrzyskie Centrum Onkologii SPZOZ, Kielce

62-500

Przychodnia Lekarska Komed, Konin

10-357

Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc, Olsztyn

39-400

Wojewodzki Szpital im. Zofii z Zamoyskich Tarnowskiej w Tarnobrzegu, Tarnobrzeg

02-781

Centrum Onkologii-Instytut im. Marii Sklodowskiej-Curie, Warsaw

03010

Hospital General de Alicante, Alicante

01120

Basken Uni. Adana Dr.Turgut Noyan Uygulama ve Arastirma Merkezi, Adana

06100

Ankara University Medical Faculty, Ankara

07059

Akdeniz Universitesi Tip Fakultesi, Antalya

03115

Kyiv City Clinical Oncological Center, Kyiv

03126

Dobryi Prognoz, Kyiv

LS9 7TF

Leeds Teaching Hospital NHS Trust. St. James University Hospital, Leeds

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Incyte Corporation

INDUSTRY