MCLA-128 With Trastuzumab/Chemotherapy in HER2+ and With Endocrine Therapy in ER+ and Low HER2 Breast Cancer.

PHASE2CompletedINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

January 15, 2018

Primary Completion Date

October 26, 2022

Study Completion Date

July 26, 2023

Conditions
Breast Cancer Metastatic
Interventions
DRUG

Zenocutuzumab

full length immunoglobulin gamma-1 (IgG1) bispecific antibody targeting Human Epidermal Growth Factor Receptor (HER)2 and HER3

DRUG

Trastuzumab

humanised IgG1 monoclonal antibody

DRUG

Vinorelbine

antineoplastic drug of vinca alkaloid family

DRUG

Endocrine therapy

same endocrine therapy is administered as the last line of endocrine therapy

Trial Locations (25)

1000

Institut Jules Bordet, Brussels

3000

UZ Leuven, Leuven

6000

Grand Hôpital de Charleroi (GHdC), Charleroi

13009

Institut Paoli Calmette, Marseille

21000

Centre Georges-Francois Leclerc, Dijon

25030

Hôpital Jean Minjoz, Besançon

28034

Ramon Y Cajal Universitary Hospital, Madrid

28041

Hospital Universitario 12de Octubre, Madrid

31100

Centre Claudius Régaud, Toulouse

37203

Sarah Cannon Research Institute, Nashville

46009

Instituto Valenciano de Oncologia, Valencia

63011

Centre Jean Perrin, Clermont-Ferrand

64131

HCA Midwest Health, Kansas City

67000

Centre Paul Strauss, Strasbourg

69008

Centre Léon Bérard, Lyon

90048

Cedars-Sinai Medical Center, Los Angeles

92210

Centre René Huguenin, Saint-Cloud

94800

Institute Gustave Roussy, Villejuif

1066 CX

Netherlands Cancer Institute NKI, Amsterdam

1400-038

Champalimaud Clinical Centre, Lisbon

4099-001

Hopistal San Antonio, Porto

4200-072

Instituto Português Oncologia, Porto

08035

Vall D'Hebron Institute of Oncology (VHIO), Barcelona

08036

Hospital Clinic. C/Villaroel, Barcelona

W1G 6AD

Sarah Cannon Research Institute UK, London

All Listed Sponsors
lead

Merus N.V.

INDUSTRY

NCT03321981 - MCLA-128 With Trastuzumab/Chemotherapy in HER2+ and With Endocrine Therapy in ER+ and Low HER2 Breast Cancer. | Biotech Hunter | Biotech Hunter