A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy

PHASE2CompletedINTERVENTIONAL
Enrollment

107

Participants

Timeline

Start Date

December 12, 2017

Primary Completion Date

June 13, 2019

Study Completion Date

June 27, 2019

Conditions
Depressive Disorder, Major
Interventions
DRUG

JNJ-42847922

Participants will receive JNJ-42847922 capsule orally.

DRUG

Placebo Matching to JNJ-42847922

Participants will receive placebo capsule matching to JNJ-42847922 orally.

DRUG

Quetiapine XR

Participants will receive quetiapine XR capsule orally.

DRUG

Placebo Matching to Quetiapine XR

Participants will receive placebo capsule matching to quetiapine XR orally.

DRUG

Selective Serotonin Reuptake Inhibitor (SSRI)

Participants will receive SSRI antidepressant (such as, citalopram, escitalopram, fluvoxamine, fluoxetine, paroxetine, sertraline, vilazodone or vortioxetine) as a part of background therapy (at the same dose, without change, every day and at approximately the same time as prior to entering the study) throughout the screening, double-blind, and follow-up phases (approximately up to Week 26).

DRUG

Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)

Participants will receive SNRI antidepressant (such as duloxetine, milnacipran, levomilnacipran, venlafaxine, desvenlafaxine) as a part of background therapy (at the same dose, without change, every day and at approximately the same time as prior to entering the study) throughout the screening, double-blind, and follow-up phases (approximately up to Week 26).

Trial Locations (50)

10019

Hapworth Psychiatric Medical PLLC, New York

11235

SPRI Clinical Trials, LLC, Brooklyn

11432

CNS Research Science, Inc., Jamaica

21218

Johns Hopkins University School of Medicine, Baltimore

27606

Carolina Partners c/o Tripha Life Sciences, Raleigh

30060

Northwest Behavioral Research Center, Marietta

33122

Premier Clinical Research, Miami

33133

Innova Clinical Trials, Miami

33134

Clinical Research of South Florida, Coral Gables

33145

Arocha Research Center Inc, Miami

33613

Stedman Clinical Trials, Tampa

34652

Suncoast Clinical Research, New Port Richey

34759

SIH Research, Kissimmee

45215

Patient Priority Clinical Sites LLC, Cincinnati

47130

American Research, LLC, Jeffersonville

48307

Rochester Center for Behavioral Medicine (RCBM), Rochester Hills

52242

University of Iowa, Iowa City

60012

RxClinicals, Crystal Lake

60076

Psychiatric Medicine Associates LLC, Skokie

60169

Alexian Brothers Health System, Hoffman Estates

60490

Suburban Clinical Research Group, Inc, Bolingbrook

63128

PsychCare Consultants Research, St Louis

63304

Midwest Research Group, Saint Charles

66208

Phoenix Medical Research, Inc., Prairie Village

72758

Woodland Research Northwest, Rogers

73069

Intend Research, Norman

73103

IPS Research Company, Oklahoma City

73112

Sooner Clinical Research, Oklahoma City

75080

Pillar Clinical Research, LLC, Richardson

76013

Hawkins Psychiatry, PC, Arlington

77030

Baylor College of Medicine, Houston

77079

Houston Endoscopy and Research Center, Inc., Houston

77081

Texas Center for Drug Development Inc, Houston

84015

Ericksen Research and Development, Clinton

85032

NoesisPharma Research, Phoenix

85283

Clinical Research Consortium Arizona, Tempe

90024

Pacific Institute of Medical Sciences, Los Angeles

90057

National Research Institute, Los Angeles

92056

Excell Research Inc, Oceanside

92103

Artemis Institute for Clinical Research, San Diego

92270

Desert Valley Research, Rancho Mirage

92374

Anderson Clinical Research, Redlands

92705

Syrentis Clinical Research, Santa Ana

92845

Collaborative NeuroScience Network, Garden Grove

98004

Northwest Clinical Research Center, Bellevue

06851

Research Center for Clinical Studies, Inc., Norwalk

02740

BTC of New Bedford, New Bedford

02135

Boston Clinical Trials & Medical Research, Roslindale

89119-5190

Clinical Research Consortium, Las Vegas

02865

BTC Network, Lincoln

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY

NCT03321526 - A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy | Biotech Hunter | Biotech Hunter