A Study to Determine the Safety and Efficacy of NT-501 in Macular Telangiectasia Type 2 - Protocol B

PHASE3CompletedINTERVENTIONAL
Enrollment

119

Participants

Timeline

Start Date

January 22, 2018

Primary Completion Date

August 31, 2022

Study Completion Date

September 23, 2022

Conditions
Macular Telangiectasia Type 2
Interventions
COMBINATION_PRODUCT

NT-501

"Each NT-501 implant consisted of hCNTF-secreting NTC-201-6A.02 cells encapsulated within supportive matrices and surrounded by a semipermeable polymer membrane.~The NTC-201-6A cells continuously secrete CNTF from the NT-501 implant into the vitreous cavity. Implanted by a qualified Health Care Professional."

PROCEDURE

Sham

The sham surgery involved a superficial conjunctival incision performed under local anesthetic and closure with a single suture.

Trial Locations (27)

2000

Save Sight Institute, Sydney, Sydney

3002

Centre for Eye Research Australia Macular Research Unit, East Melbourne

14642

Flaum Eye - University of Rochester, Rochester

University of Rochester Strong Memorial Hospital, Rochester

19104

Scheie Eye Institute - University of Pennsylvania, Philadelphia

21237

Elman Retina Group, PA, Baltimore

29169

Palmetto Retina Center, West Columbia

30322

Emory University Eye Center, Atlanta

37922

Southeastern Retina Associates, PC, Knoxville

45242

Cincinnati Eye Institute, Cincinnati

48105

University of Michigan, Kellogg Eye Center, Ann Arbor

48145

St. Franziskus, Muenster, Münster

53127

University of Bonn, Bonn

55905

Mayo Clinic, Rochester

60611

Northwestern Medical Group, Chicago

63017

The Retina Institute, Chesterfield

74114

Tulsa Retina Consultants, Tulsa

76092

Retina Center of Texas, Southlake

77401

Retina Consultants of Texas, Bellaire

78705

Austin Clinical Research, LLC, Austin

79106

Klinik at Freiberg, Germany, Freiburg im Breisgau

80909

Retina Consultants of Southern Colorado, P.C., Colorado Springs

90211

Retina Vitreous Assoc, Beverly Hills

97221

Retina Northwest, PC, Portland

02114

Massachusetts Eye and Ear Infirmary Ophthalmology Clinical Research Office, Boston

01107

New England Retina Consultants, Springfield

07003

Retina Center of New Jersey - Envision Ocular, LLC, Bloomfield

Sponsors
All Listed Sponsors
collaborator

The Lowy Medical Research Institute Limited

OTHER

lead

Neurotech Pharmaceuticals

INDUSTRY