Plasma CO2 Removal Due to CRRT and Its Influence on Indirect Calorimetry

NACompletedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

April 26, 2017

Primary Completion Date

March 15, 2019

Study Completion Date

March 15, 2019

Conditions
Continuous Renal Replacement TherapyCO2 RemovalNutrition PoorAcute Renal Failure
Interventions
DIAGNOSTIC_TEST

blood gas analysis under citrate predilution

blood gas analysis of blood on different sample points and dialysis fluid

DEVICE

filter replacement

Using local protocol: stop and disconnect CRRT, replace filter and reconnect and restart CRRT.

DEVICE

IC

monitor patients during the whole study period with indirect calorimetry

DRUG

NaCl predilution

Replace citrate predilution with NaCl

DIAGNOSTIC_TEST

blood gas analysis under NaCl predilution

repeat blood gas analysis of blood on different sample points and dialysis fluid

DRUG

double ultrafiltration

double the ultrafiltration fluid by augmenting post dilution fluid and keeping ultrafiltration at the same rate.

DIAGNOSTIC_TEST

blood gas analysis under citrate predilution and double ultrafiltration rate

repeat blood gas analysis of blood on different sample points and dialysis fluid

DIETARY_SUPPLEMENT

pause and restart nutritional therapy

pause parenteral and enteral nutrition before indirect calorimetry is performed. and restart after first blood analysis for vitamine status

DIAGNOSTIC_TEST

evolution of vitamin and trace elements

blood analysis for vitamin and trace elements. Perform this blood analysis after restart of CRRT but before restart of nutritional therapy, 30 minutes after restart of nutritional therapy and 24h after restart of nutritional therapy.

Trial Locations (1)

1090

universitair ziekenhuis Brussel, Brussels

All Listed Sponsors
lead

Universitair Ziekenhuis Brussel

OTHER

NCT03314363 - Plasma CO2 Removal Due to CRRT and Its Influence on Indirect Calorimetry | Biotech Hunter | Biotech Hunter