Study of ASTX727 vs IV Decitabine in Participants With MDS, CMML, and AML

PHASE3CompletedINTERVENTIONAL
Enrollment

227

Participants

Timeline

Start Date

February 15, 2018

Primary Completion Date

September 10, 2021

Study Completion Date

May 25, 2023

Conditions
Myelodysplastic SyndromesChronic Myelomonocytic LeukemiaAcute Myeloid Leukemia
Interventions
DRUG

ASTX727

ASTX727 oral tablet

DRUG

Dacogen

Decitabine 20 mg/m\^2 one-hour IV infusion

Trial Locations (84)

4032

Debreceni Egyetem Klinikai Kozpont, Debrecen

4600

Klinikum Wels-Grieskirchen, Wels

6725

University of Szeged, Szeged

7400

Somogy Megyei KAposi Mor Oktato Korhaz, Kaposvár

University of Pecs, 1st Department of Internal Medicine, Pécs

10003

Hospital San Pedro de Alcantara, Cáceres

10034

Fakultni Nemocnice Kralovske Vinohrady FNKV, Prague

10065

Weill Cornell Medicine, New York

10467

Montefiore, The Bronx

11042

Monter Cancer Center, Lake Success

14263

Roswell Park, Buffalo

15121

Azienda Ospedaliera Nazionale SS. Antonio e Biagio e C. Arrigo, Alessandria

15224

West Penn Allegheny Cancer Institute, Pittsburgh

15232

University of Pittsburgh Hillman Cancer Center, Pittsburgh

18012

Hospital Universitario Virgen de las Nieves, Granada

20007

Georgetown University, Washington D.C.

20122

Fondazione IRCCS C Granda OM Policlinico, Milan

20817

Regional Cancer Care Associates, Bethesda

Oregon Health & Sciences University, Portland

21287

Johns Hopkins, Baltimore

23538

UNIVERSITTSKLINIKUM Schleswig-Holstein, Lübeck

28007

Hospital General Universitario Gregorio Marañón, Madrid

28027

Clinica Universitaria Navarra, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28100

Azienda Ospedaliero-Universitaria Maggiore della Carità Novara, Novara

29414

Charleston Hematology Oncology Associates, Charleston

31008

Clinica Universitaria Navarra, Pamplona

33011

Hospital Universitario Central de Asturias, Oviedo

33140

Mount Sinai, Miami Beach

33308

Holy Cross Hospital, Fort Lauderdale

33322

Boca Raton Clinical Research, Boca Raton

35033

Philipps-Universität Marburg, Klinik für Innere medizin, Hämatologie, Onkologie und Immunologie, Marburg

36100

ULSS 8 Vicenza - Ospedale San Bortolo di Vicenza, Vicenza

36207

Pinnacle Research Group, Anniston

37007

Hospital Universitario de Salamanca, Salamanca

37232

Vanderbilt, Nashville

38114

Staedtisches Klinikum Braunschweig, Braunschweig

39008

Hospital U. Marqués de Valdecilla, Santander

40207

Norton Cancer Institute, Louisville

40479

Oberärztin für Innere Medizin, Hämato-/Onkologie und Palliativmedizin, Düsseldorf

43210

Ohio State University, Columbus

44718

Gabrail Cancer Center, Canton

46026

Hospital Universitari I Politècnic La Fe, Valencia

46237

Indiana Blood and Marrow Transplantation, Indianapolis

48334

Michigan Center of Medical Research, Farmington Hills

49503

Cancer & Hematology Centers of Western Michigan, Grand Rapids

50134

AOUC Azienda Ospedaliero-Universitaria Careggi, Florence

55905

Mayo Clinic Rochester, Rochester

60612

Rush University Medical Center, Chicago

60637

University of Chicago, Chicago

62301

Quincy Medical Group, Quincy

62500

University Hospital Brno, Brno

68100

Hospital Emile Muller, Mulhouse

69008

Centre de lutte contre le Cancer Leon Berard, Lyon

75246

Baylor Scott & White University Medical Center, Dallas

77030

Houston Methodist Cancer Center, Houston

MD Anderson Cancer Center, Houston

79106

Universitaetsklinikum Freiburg, Freiburg im Breisgau

84124

Utah Cancer Specialists, Salt Lake City

85054

Mayo Clinic Arizona, Phoenix

85715

Arizona Clinical Research Center, Tucson

90007

University of Southern California, Los Angeles

92708

Compassionate Cancer Care Research Group, Fountain Valley

98109

Fred Hutchinson Cancer Research Center, Seattle

99336

Kadlec Clinic Hematology and Oncology, Kennewick

06510

Yale, New Haven

07601

Hackensack, Hackensack

75390-9179

University of Texas Southwestern Medical Center, Dallas

05020

Uniklinikum Salzburg, Salzburg

01130

General Hospital Hietzing, Vienna

T6G 2B7

University of Alberta Hospital, Edmonton

B3H 2Y9

Queen Elizabeth II (QEII) Health Sciences Center, Halifax

L8V 1C3

Juravinski Hospital & Cancer Center, Hamilton

K1H8L6

Ottawa Hospital - General Campus, Ottawa

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

M5G 2M9

Princess Margaret Cancer Center - University Health Network, Toronto

H1T 2M4

Centre Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) de l'Est-de-l'Ile-de-Montréal - Hôpital Maisonneuve Rosemont, Montreal

708 00

FN Ostrava, Ostrava

06120

University Hospital Halle, Halle

04103

University of Leipzig, Leisnig

00144

Ospedale S. Eugenio, Rome

08909

Hospital Duran i Reynals, L'Hospitalet de Llobregat

OX3 7LE

Oxford University Hopsitals NHS Trust, Oxford

M20 4BX

The Christie NHS Fundation Trust, Manchester

Sponsors
All Listed Sponsors
lead

Astex Pharmaceuticals, Inc.

INDUSTRY