Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip

PHASE3CompletedINTERVENTIONAL
Enrollment

1,650

Participants

Timeline

Start Date

October 26, 2017

Primary Completion Date

December 13, 2019

Study Completion Date

November 9, 2020

Conditions
Osteoarthritis, KneeOsteoarthritis, Hip
Interventions
DRUG

Fasinumab

Solution for injection in pre-filled syringe

OTHER

Diclofenac

NSAID active comparator (capsule)

OTHER

Celecoxib

NSAID active comparator (capsule)

DRUG

Matching placebo

Fasinumab-matching placebo (solution for injection in pre-filled syringe); NSAID-matching placebo (capsule)

Trial Locations (71)

10530

Drug Trials America, Hartsdale

11021

Northwell Health, Great Neck

11230

Drug Trial Brooklyn, Brooklyn

14221

Upstate Clinical Research Associates, LLC, Williamsville

15701

Center for Orthopaedics and Sports Medicine, Indiana

22911

Charlottesville Medical Research Center LLC, Charlottesville

23606

Health Research of Hampton Roads, Inc, Newport News

27103

The Center For Clinical Research, Winston-Salem

28150

Carolina Research Center, Shelby

28401

PMG Research of Wilmington LLC, Wilmington

29118

ACME Research, LLC, Orangeburg

29406

Coastal Carolina Research Center at LowCountry Orthopaedics, North Charleston

29601

Piedmont Comprehensive Pain Management Group, Greenville

29621

Radiant Research, Inc., Anderson

29651

Radiant Research, Inc., Greer

29707

Piedmont Research Partners, LLC, Old Point Station

30060

Drug Studies America, Marietta

Georgia Institute For Clinical Research LLC, Marietta

30189

North Georgia Clinical Research, Woodstock

32127

Progressive Medical Research, Port Orange

32514

Gulf Region Clinical Research institute, Pensacola

32720

Avail Clinical Research, LLC, DeLand

32806

Bioclinica Research, Orlando

33014

Lakes Research, LLC, Miami Lakes

33144

AMB Research Center, Inc, Miami

33155

Allied Biomedical Research Institute, Miami

33324

Integral Rheumatology & Immunology Specialists (IRIS), Plantation

36207

Pinnacle Research Group, Llc, Anniston

36608

Horizon Research Partners, Mobile

38119

Office of Dr.Ramesh C. Gupta MD, Memphis

40213

L-MARC Research Center, Louisville

43213

Aventiv Research Inc, Columbus

45242

New Horizons Clinical Research, Cincinnati

45432

DOC Clinical Research, Dayton

47714

Clinical Research Advantage, Inc., Evansville

MediSphere Medical Research Center, LLC, Evansville

48706

Great Lakes Research Group, Inc., Bay City

48723

Onyx Clinical Research, Caro

55423

Synexus Clinical Research US, Inc., Richfield

60453

Affinity Clinical Research Institute, Oak Lawn

60607

Chicago Clinical Research Institute, Inc, Chicago

68022

Skyline Medical Center /Radiant Research, Inc., Elkhorn

68134

Meridian Clinical Research Associates, LLC, Omaha

70072

Tandem Clinical Research, Marrero

75075

Clinical Investigations Of Texas, Plano

75093

Synexus USA, Plano

79410

West Texas Clinical Research, Lubbock

80209

Mountain View Clinical Research, Denver

85020

Synexus Central Phoenix Medical Clinic, Phoenix

85224

Clinical Research Advantage, Inc./Warner Family Practice, PC, Chandler

85283

Clinical Research Consortium Arizona, Tempe

87102

Albuquerque Clinical Trials, Inc., Albuquerque

89144

Robert Kaplan, D.O., Las Vegas

91360

Westlake Medical Research, Thousand Oaks

91763

Catalina Research Institute, LLC, Montclair

91978

Encompass Clinical Research, Spring Valley

92020

TriWest Research Associates, LLC, El Cajon

92083

Synexus Clinical Research US, Inc., Vista

92103

Advanced Research Center, Inc, San Diego

92123

California Research Foundation, San Diego

92703

Paragon Rx Clinical Research, Inc, Santa Ana

92805

Advance Research Center, Anaheim

92840

Paragon Rx Clinical Research, Inc., Garden Grove

95661

Sierra Clinical Research, Roseville

95817

UC Davis Center for Musculoskeletal Health, Sacramento

99218

Spokane Joint Replacement Center, Spokane

06606

New England Research Associates, LLC, Bridgeport

06157

CRM of Greater New Haven, LLC, Hamden

06905

Stamford Therapeutics Consortium, Stamford

02111

Tufts Medical Center, Inc., Boston

08869

Amici Clinical Research, LLC, Raritan

All Listed Sponsors
collaborator

Teva Pharmaceutical Industries, Ltd.

INDUSTRY

lead

Regeneron Pharmaceuticals

INDUSTRY

NCT03304379 - Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip | Biotech Hunter | Biotech Hunter