3,356
Participants
Start Date
May 4, 2017
Primary Completion Date
June 30, 2022
Study Completion Date
November 30, 2022
Deeplex test, MolBio TrueNat for 2nd line, GeneXpert 2nd line
"Improvement of the diagnosis of Multi Drug Resistant-Tuberculosis patients with culture-free approaches. We have planned to diagnose Tuberculosis resistance to 1st and 2nd line drugs through novel molecular multiplex assays (Study 1) by:~* Validating the Deeplex test and establish a network for shipment of sputum samples in ethanol to regional reference laboratories (Study 1 - phase 1)~* Validating the Molbio Truenat test as a point of care test (Study 1 - phase 2)~* Validating the Cepheid GeneXpert 2nd line cartridge at the district level (Study 1 -phase2)"
Fluorescein DiAcetate (FDA) Microscopy,GeneXpert Ct value, pre-rRNA synthesis
"Improvement of the management of Multi Drug Resistant-Tuberculosis patients with culture-free approaches. We have planned to set up alternative culture-free approaches for the monitoring of patients' response to Multi Drug Resistant-Tuberculosis treatment (Study 2), with:~* FDA microscopy~* Measurement of bacterial load by following Cycle threshold (Ct) values in GeneXpert Mycobacterium tuberculosis/Rifampicin~* Measurement of pre-rRNA synthesis"
Institute of Tropical Medecine, Antwerp
The Tuberculosis Reference Laboratory Bamenda, Bamenda
Institut National de Recherche Biomédicale (INRB), Kinshasa
Jimma University, Jīma
Service de Pneumophtisiologie, Hôpital Ignace Deen, Conakry, Conakry
Université des Sciences, des Techniques et des Technologies de Bamako, SEREFO, Bamako
Damien Fundation, Ibadan
Rwanda Biomedical Center (RBC), Kigali
Université Cheick Anta Diop (UCAD), Dakar
Centre National Hospitalier Universitaire de Pneumo-Phtisiologie de Cotonou, Cotonou
Collaborators (1)
Rwanda Biomedical Centre
OTHER
The Tuberculosis Reference Laboratory Bamenda
UNKNOWN
Institut National de Recherche Biomédicale. Kinshasa, République Démocratique du Congo
OTHER
Jimma University
OTHER
Service de Pneumophtisiologie, Hôpital Ignace Deen
UNKNOWN
University of the Sciences, Techniques and Technologies of Bamako
OTHER
Damien Foundation
OTHER
Cheikh Anta Diop University, Senegal
OTHER
Institute of Tropical Medicine, Belgium
OTHER
World Health Organization
OTHER
London School of Hygiene and Tropical Medicine
OTHER
Genoscreen
OTHER
Dissou AFFOLABI
OTHER_GOV