Study of Pembrolizumab Given With Ipilimumab or Placebo in Participants With Untreated Metastatic Non-Small Cell Lung Cancer (NSCLC) (MK-3475-598/KEYNOTE-598)

PHASE3CompletedINTERVENTIONAL
Enrollment

568

Participants

Timeline

Start Date

December 14, 2017

Primary Completion Date

September 1, 2020

Study Completion Date

September 7, 2022

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
BIOLOGICAL

Pembrolizumab

Administered as an intravenous (IV) infusion every 3 weeks (Q3W)

BIOLOGICAL

Ipilimumab

Administered as an IV infusion every 6 weeks (Q6W)

OTHER

Placebo

Normal saline solution administered as an IV infusion Q6W

Trial Locations (187)

104

Mackay Memorial Hospital ( Site 2405), Taipei

404

China Medical University Hospital ( Site 2403), Taichung

833

Chang Gung Medical Foundation - Kaohsiung ( Site 2404), Kaohsiung City

1002

Pauls Stradins Clinical University Hospital ( Site 1100), Riga

1079

Riga East Clinical University Hospital ( Site 1111), Riga

1121

Orszagos Koranyi TBC es Pulmonologiai Intezet ( Site 1502), Budapest

1122

Orszagos Koranyi TBC es Pulmonologiai Intezet ( Site 1506), Budapest

Orszagos Onkologiai Intezet ( Site 1509), Budapest

1448

Clinton Onclogy Clinic ( Site 1804), Alberton

2050

Chris OBrien Lifehouse ( Site 2100), Camperdown

2193

Charlotte Maxeke Johannesburg Academic Hospital ( Site 1806), Johannesburg

2196

Sandton Oncology Medical Group PTY LTD ( Site 1807), Johannesburg

3065

St Vincents Hospital Melbourne ( Site 2101), Fitzroy

4001

Dr G.A. Landers Specialist Oncologist ( Site 1803), Durban

4032

Debreceni Egyetem Klinikai Kozpont ( Site 1511), Debrecen

4101

Mater Cancer Care Centre ( Site 2102), South Brisbane

4814

The Townsville Hospital ( Site 2103), Douglas

5000

Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 1501), Szolnok

5700

Bekes Megyei Pandy Kalman Korhaz. ( Site 1507), Gyula

6150

Fiona Stanley Hospital ( Site 2105), Perth

7405

Vincent Pallotti Hospital ( Site 1811), Cape Town

7570

GVI Oncology Clinical Research Centre ( Site 1802), Kraaifontein

8000

Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz ( Site 1504), Székesfehérvár

University of Stellenbosch and Tygerberg Hospital ( Site 1810), Cape Town

8582

Veszprem Megyei Tudogyogyintezet ( Site 1503), Farkasgyepű

9024

Petz Aladar Megyei Oktato Korhaz ( Site 1505), Győr

9301

Universitas Annex National Hospital ( Site 1800), Bloemfontein

10003

Hospital San Pedro de Alcantara ( Site 1208), Cáceres

10029

Icahn School of Medicine at Mount Sinai ( Site 0034), New York

10048

National Taiwan University Hospital ( Site 2400), Taipei

10330

Chulalongkorn Hospital ( Site 2561), Bangkok

10400

Ramathibodi Hospital. ( Site 2563), Ratchthevee

Pramongkutklao Hospital ( Site 2564), Bangkok

10700

Siriraj Hospital ( Site 2562), Bangkok

13007

Clinica Peruano Americana S.A. ( Site 0703), Trujillo

13015

Hopital Nord du Marseille ( Site 0808), Marseille

13125

Evangelische Lungenklinik Berlin ( Site 0903), Berlin

13585

Vivantes Klinikum Spandau ( Site 0910), Berlin

14050

Medica Sur S.A.B de C.V. ( Site 0608), Mexico City

14165

HELIOS Klinikum Emil von Behring ( Site 0905), Berlin

15033

Hospital Nacional Guillermo Almenara Irigoyen ( Site 0705), La Victoria

15036

Clinica Internacional Sede San Borja ( Site 0701), Lima

15102

Hospital Nacional Cayetano Heredia ( Site 0706), Lima

16059

Uludag Universitesi Tip Fakultesi ( Site 1914), Bursa

18009

Cherkasy Regional Hospital ( Site 2020), Cherkasy

20089

Humanitas Research Hospital ( Site 1004), Rozzano

20141

Istituto Europeo di Oncologia ( Site 1007), Milan

20900

Ospedale San Gerardo ASST Monza ( Site 1002), Monza

22030

Trakya Uni. Tip Fakultesi ( Site 1911), Edirne

22927

LungenClinic Grosshansdorf GmbH ( Site 0908), Großhansdorf

23538

Universitaetsklinikum Schleswig Holstein. ( Site 0918), Lübeck

25006

PP PPC Acinus Medical and Diagnostic Centre ( Site 2002), Kropyvnytskyi

25123

ASST Spedali Civili ( Site 1001), Brescia

28040

Hospital Fundacion Jimenez Diaz - Clin. Concepcion ( Site 1209), Madrid

29200

CHU de Brest. Hopital Morvan ( Site 0800), Brest

29615

Greenville Health System ( Site 8010), Greenville

31059

CHU de Toulouse - Hopital Larrey ( Site 0801), Toulouse

32804

Florida Hospital Cancer Institute ( Site 0009), Orlando

33076

Institut Bergonie ( Site 0803), Bordeaux

33305

Chang Gung Memorial Hospital - Linkou Branch ( Site 2402), Taoyuan District

34098

Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 1906), Istanbul

34899

Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 1912), Istanbul

35001

Hospital Universitario Insular de Gran Canaria ( Site 1203), Las Palmas de Gran Canaria

35100

Ege Universitesi Tip Fakultesi Hastanesi ( Site 1901), Izmir

35575

Medical Park Izmir Hospital ( Site 1900), Izmir

37045

Ospedale Mater Salutis ( Site 1005), Legnago

37403

University of Tennessee Erlanger Oncology & Hematology ( Site 0026), Chattanooga

37909

Tennessee Cancer Specialists ( Site 0017), Knoxville

40002

Khon Kaen University ( Site 2565), Khon Kaen

41013

Hospital Universitario Virgen del Rocio ( Site 1200), Seville

41380

Kocaeli Universitesi Tip Fakultesi ( Site 1909), Kocaeli

42003

Mercy Health-Paducah Medical Oncology and Hematology ( Site 0018), Paducah

43210

The Ohio State University Wexner Medical Center ( Site 0016), Columbus

43219

Mid Ohio Oncology/Hematology Inc. ( Site 0003), Columbus

44200

Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0603), Guadalajara

44280

Inonu Universitesi Tip Fakultesi ( Site 1907), Malatya

49102

Dnipropetrovsk City Multidiscipline Clinical Hosp.4 of DRC ( Site 2000), Dnipropetrovsk

50000

Bangkok Hospital Chiangmai ( Site 2560), Mueang

50006

Changhua Christian Hospital ( Site 2406), Changhua

50048

MI Kryviy Rih Center of Dnipropetrovsk Regional Council ( Site 2005), Kryviy Rih

53226

Medical College of Wisconsin Clinical Cancer Center ( Site 0027), Milwaukee

53792

University of Wisconsin Carbone Cancer Center ( Site 0004), Madison

58013

Regional Clinical Onco Dispensary_ State Medical University ( Site 2012), Chernivtsy

59037

C.H.R.U de Lille - Hopital Calmette ( Site 0805), Lille

61080

Karadeniz Teknik Universitesi ( Site 1910), Trabzon

64710

Avix Investigacion Clinica S.C. ( Site 0600), Monterrey

65055

MI Odessa Regional Oncological Centre ( Site 2004), Odesa

67091

Nouvel Hopital Civil ( Site 0809), Strasbourg

69126

Universitaetsklinikum Heidelberg ( Site 0900), Heidelberg

70457

National Cheng Kung University Hospital ( Site 2401), Tainan City

71013

IRCCS Casa Sollievo della Sofferenza ( Site 1009), San Giovanni Rotondo (FG)

72037

Centre Hospitalier Le Mans ( Site 0804), Le Mans

72530

Oncologica de Puebla SA de CV ( Site 0606), Puebla City

75020

Hopital Tenon ( Site 0810), Paris

75028

Texas Oncology-Flower Mound ( Site 8007), Flower Mound

75203

Texas Oncology-Methodist Dallas Cancer Center ( Site 8000), Dallas

75601

Texas Oncology-Longview Cancer Center ( Site 8009), Longview

76014

Texas Oncology-Arlington South ( Site 8006), Arlington

76018

MI Prykarpatskyi Clinical Oncology Centrum ( Site 2009), Ivano-Frankivsk

79031

Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 2003), Lviv

80131

AORN dei Colli Plesso Monaldi ( Site 1003), Napoli

85054

Mayo Clinic Cancer Center ( Site 0007), Phoenix

90404

John Wayne Cancer Institute ( Site 0021), Santa Monica

91505

Disney Family Cancer Center ( Site 0035), Burbank

93940

Pacific Cancer Care ( Site 0001), Monterey

94010

Centre Hopitalier Intercommunal Creteil ( Site 0802), Créteil

97070

Medical Care and Research S.A. de C.V. ( Site 0602), Mérida

97213

Providence Cancer Institute, Franz Clinic - Eastside ( Site 0031), Portland

98684

Northwest Cancer Specialists, P.C. ( Site 8001), Vancouver

98902

Virginia Mason Memorial- North Star Lodge Cancer Center ( Site 0033), Yakima

110221

Centro de Investigacion Clinica del Country ( Site 0500), Bogotá

110311

Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 0506), Bogotá

230002

Oncomedica S.A. ( Site 0502), Montería

520001

Instituto Cancerologico de Narino Ltda ( Site 0504), Pasto

2520000

Hospital Clinico Vina del Mar ( Site 0400), Viña del Mar

3465584

Clinica Universidad Catolica del Maule ( Site 0413), Talca

7500006

Soc. Prosalud Montes y Orlandi Ltda (Orlandi Oncologia) ( Site 0401), Santiago

8330032

Pontificia Universidad Catolica de Chile ( Site 0404), Santiago

8380455

Instituto Nacional del Cancer ( Site 0406), Santiago

04074

New England Cancer Specialists ( Site 0019), Scarborough

02118

Boston Medical Center ( Site 0025), Boston

01805

Lahey Hospital & Medical Center ( Site 0020), Burlington

07666

Holy Name Medical Center ( Site 0022), Teaneck

R8500ACE

Centro de Investigaciones Clinicas - Clinica Viedma ( Site 0202), Viedma

S2000DSV

Sanatorio Parque ( Site 0201), Rosario

C1118AAT

Hospital Aleman ( Site 0208), Buenos Aires

X5016KEH

Hospital Privado Centro Medico Cordoba ( Site 0206), Córdoba

F5300COE

Centro Oncologico Riojano Integral ( Site 0203), La Rioja

S2000CVB

Sanatorio Britanico ( Site 0205), Rosario

S2000KZE

Instituto de Oncologia de Rosario ( Site 0200), Rosario

T4000IAK

Centro Medico San Roque ( Site 0207), San Miguel de Tucumán

50070-550

Inst de Medicina Integral Professor Fernando Figueira- IMIP ( Site 0302), Recife

91350-200

Hospital Nossa Senhora da Conceicao ( Site 0306), Porto Alegre

97015-513

Clinica de Hematologia e Oncologia Viver Ltda ( Site 0305), Santa Maria

01246-000

Instituto do Cancer de Sao Paulo - ICESP ( Site 0300), São Paulo

01323-020

Hospital Alemao Oswaldo Cruz ( Site 0311), São Paulo

04024-002

Escola Paulista de Medicina - UNIFESP ( Site 0304), São Paulo

14784-400

Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0312), Barretos

88034-000

CEPON Centro de Pesquisa Oncológicas ( Site 0307), Florianópolis

04039-004

Hospital do Servidor Publico do Estado ( Site 0308), São Paulo

T2N 4N2

Tom Baker Cancer Centre ( Site 0119), Calgary

R3E 0V9

CancerCare Manitoba ( Site 0106), Winnipeg

G7H 5H6

CIUSSS du Saguenay-Lac-St-Jean ( Site 0115), Chicoutimi

J4V 2H1

CISSS de la Monteregie-Centre ( Site 0100), Greenfield Park

G6V 3Z1

CISSS-CA Hotel-Dieu de Levis ( Site 0108), Lévis

H3T 1M5

CIUSSS Ouest de l'Ile - St-Mary's Hospital ( Site 0107), Montreal

J7Z 5T3

St-Jerome Medical Research Inc ( Site 0113), Saint-Jérôme

050034

Hospital Pablo Tobon Uribe ( Site 0505), Medellín

07548

SRH Waldklinikum Gera GmbH ( Site 0907), Gera

04103

Universitaetsklinikum Leipzig ( Site 0919), Leipzig

D09 V2N0

Beaumont Hospital ( Site 1312), Dublin

Dublin 8

St James Hospital ( Site 1401), Dublin

V94 F858

University Hospital Limerick ( Site 1403), Limerick

06132

Ospedale Santa Maria della Misericordia ( Site 1008), Perugia

03310

Grupo Medico Camino SC ( Site 0607), Mexico City

04000

Centro Especializado de Enfermedades Neoplasicas SRL-CEEN SRL ( Site 0710), Arequipa

Instituto Regional de Enfermedades Neoplasicas del Sur IRENSUR ( Site 0704), Arequipa

53-413

Dolnoslaskie Centrum Onkologii. ( Site 1616), Wroclaw

75-581

Szpital Wojewodzki w Koszalinie im. Mikolaja Kopernika ( Site 1614), Koszalin

95-060

Powiatowe Centrum Zdrowia w Brzezinach ( Site 1615), Brzeziny

85-796

Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1609), Bydgoszcz

62-500

Przychodnia Lekarska Komed ( Site 1602), Konin

10-357

Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc ( Site 1607), Olsztyn

60-693

MED-POLONIA Sp. z o.o. ( Site 1605), Poznan

02-781

Centrum Onkologii-Instytut im. Marii Skłodowskiej-Curie ( Site 1600), Warsaw

0081

Wilgers Oncology Centre ( Site 1808), Pretoria

03080

Seoul National University Hospital ( Site 2303), Seoul

03722

Severance Hospital Yonsei University Health System ( Site 2300), Seoul

05505

Asan Medical Center ( Site 2302), Seoul

06351

Samsung Medical Center ( Site 2301), Seoul

08916

Hospital Germans Trias i Pujol ( Site 1207), Badalona

08908

Hospital Duran i Reynals ( Site 1201), L'Hospitalet de Llobregat

08035

Hospital Universitari Vall d Hebron ( Site 1211), Barcelona

01130

Acibadem Adana Hastanesi ( Site 1904), Adana

06100

Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1908), Ankara

06490

Ankara Sehir Hastanesi ( Site 1903), Cankaya - Ankara

03002

National Cancer Institute of the MoH of Ukraine ( Site 2015), Kyiv

03115

Kyiv City Clinical Oncological Center ( Site 2014), Kyiv

TR1 3LJ

Royal Cornwall Hospital ( Site 1325), Truro

SM2 5PT

The Royal Marsden NHS Foundation Trust. ( Site 1326), Sutton

BT9 7AB

Belfast City Hospital ( Site 1302), Belfast

NW3 2QG

Royal Free NHS Foundation Trust ( Site 1324), London

SW17 0QT

St. Georges University Hospital NHS Foundation Trust ( Site 1321), London

SW3 6JJ

The Royal Marsden NHS Foundation Trust.. ( Site 1327), London

M20 4BX

The Christie NHS Foundation Trust ( Site 1301), Manchester

HA6 2RN

Mount Vernon Cancer Centre ( Site 1307), Northwood

WV10 0QP

Royal Wolverhampton Hospitals NHS Trust ( Site 1323), Wolverhampton

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03302234 - Study of Pembrolizumab Given With Ipilimumab or Placebo in Participants With Untreated Metastatic Non-Small Cell Lung Cancer (NSCLC) (MK-3475-598/KEYNOTE-598) | Biotech Hunter | Biotech Hunter