Avelumab With Chemoradiation in Locally Advanced Rectal Cancer

Avelumab 10 mg/Kg every 2 weeks for 4 cycles post LCCRT

5FU continuous infusion 225mg/m2/day during radiotherapy

Can be administered in place of 5FU infusion. Dose = 825 mg/m2 twice a day on each day of radiotherapy

50.4 Gy in 28 fractions delivered over 5.5 weeks as 5 fractions/week

Surgical resection of tumour mass post radiotherapy and chemotherapy