2,387
Participants
Start Date
April 4, 2018
Primary Completion Date
January 31, 2023
Study Completion Date
March 31, 2023
ICSI
All patients will receive controlled ovarian hyperstimulation (COH) treatment, which is performed by standard routines at each study center. The COH treatment includes either gonadotrophin-releasing hormone agonist (GnRH-a) protocol or gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol.Oocyte retrieval is scheduled for 36 (±2) after hCG injection.The retrieved cumulus oocyte complexes (COC) will be allocated to undergo routine ICSI procedure according to the result of randomization in each study site.
Conventional IVF
All patients will receive controlled ovarian hyperstimulation (COH) treatment, which is performed by standard routines at each study center. The COH treatment includes either gonadotrophin-releasing hormone agonist (GnRH-a) protocol or gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol.Oocyte retrieval is scheduled for 36 (±2) after hCG injection.The retrieved cumulus oocyte complexes (COC) will be allocated to undergo conventional IVF procedure according to the result of randomization in each study site.
Peking University third Hospital, Beijing
First Affiliated Hospital of Anhui Medical University, Hefei
The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou
General Hospital of Ningxia Medical University, Yinchuan
Haidian Maternal and Child Health Hospital, Beijing
The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou
International Peace Maternity and Child Health Hospital of Shanghai Jiao Tong University, Shanghai
First Affiliated Hospital of Kunming Medical University, Kunming
Women's Hospital of Zhejiang University, Hangzhou
The Second Hospital of Hebei Medical University, Shijiazhuang
International Peace Maternity and Child Health Hospital
OTHER
Women's Hospital School Of Medicine Zhejiang University
OTHER
Sixth Affiliated Hospital, Sun Yat-sen University
OTHER
First Affiliated Hospital of Kunming Medical University
OTHER
Beijing Haidian Maternal and Child Health Hospital
OTHER
The First Affiliated Hospital of Anhui Medical University
OTHER
The Second Hospital of Hebei Medical University
OTHER
The Third Affiliated Hospital of Guangzhou Medical University
OTHER
General Hospital of Ningxia Medical University
OTHER
Jie Qiao
OTHER