Influence of Shunt Occlusion on Organ Functions in Hyperammonemic Patients With Cirrhosis Having Porto-systemic Shunt.

NACompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

July 3, 2017

Primary Completion Date

July 31, 2019

Study Completion Date

July 31, 2019

Conditions
Cirrhosis
Interventions
PROCEDURE

Shunt Occlusion

Catheterization of the Porto-systemic shunt (via the left renal vein for gastro-lienorenal shunt) will be accomplished using a catheter and occlusion will be performed with balloon catheter/vascular plug. Occlusion venography is then performed to define the type of varix/varices and the anatomy of the venous drainage followed by infusion of sclerosant. The occluded balloon were inflated and remained in place for a maximum of 24 hours deflated under fluoroscopy the next day/plug is deployed and sclerosant is injected to obliterate the shunt and follow up CT is done to look for completion on the next day. Follow up CT abdomen is done periodically to look for effect on shunt and organ.

DIETARY_SUPPLEMENT

Standard Medical Treatment (SMT)

These will include diet rich in BCAA (branch chain amino acids), laxatives and rifaximin

Trial Locations (1)

110070

Institute of Liver and Biliary Sciences, New Delhi

All Listed Sponsors
lead

Institute of Liver and Biliary Sciences, India

OTHER

NCT03293459 - Influence of Shunt Occlusion on Organ Functions in Hyperammonemic Patients With Cirrhosis Having Porto-systemic Shunt. | Biotech Hunter | Biotech Hunter