DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore

NACompletedINTERVENTIONAL
Enrollment

136

Participants

Timeline

Start Date

December 1, 2017

Primary Completion Date

December 1, 2019

Study Completion Date

June 1, 2020

Conditions
Infertility, Female
Interventions
DRUG

human menopausal gonadotropin

human menopausal gonadotropin subcutaneously

DRUG

GnRH antagonist

GnRH antagonist subcutaneously

DRUG

GnRH analog

GnRH analog subcutaneously

PROCEDURE

Trophectoderm biopsy

Trophectoderm biopsy is the process of removing few cells from an in vitro fertilization embryo.

DIAGNOSTIC_TEST

MitoScore

The cells removed from an in vitro fertilization embryo during the trophectoderm biopsy will be used to assess the mitochondrial DNA content as a viability indicator in the euploid embryos.

PROCEDURE

Intracytoplasmic sperm injection

ICSI is an in vitro fertilization procedure in which a single sperm is injected directly into an oocyte.

PROCEDURE

Ovarian puncture

Egg retrieval is a simple procedure. It is performed in an operating room for safety reasons. It is performed vaginally and involves aspirating the follicular fluid through a thin needle. Embryologists then retrieve from this fluid the eggs that have matured during stimulation. It lasts for 5 to 15 minutes, and a mild sedative is administered to prevent any kind of pain during the procedure.

DIAGNOSTIC_TEST

Preimplantation genetic test

The cells removed from an in vitro fertilization embryo during the trophectoderm biopsy will be tested for chromosomal normalcy before transferring the embryo to the uterus.

PROCEDURE

Embryo transfer

Embryo transfer refers to a step in the process of assisted reproduction in which embryos are placed into the uterus

DIAGNOSTIC_TEST

Pregnancy test

A pregnancy test is used to determine whether a woman is pregnant.

PROCEDURE

Embryo freezing

Embryo freezing is a method for cryopreserving embryos.

PROCEDURE

Embryo thawing

Embryo thawing is the procedure to recover previously frozen embryos prior to an embryo transfer.

Trial Locations (1)

28035

IVI Madrid, Madrid

All Listed Sponsors
lead

IVI Madrid

OTHER

NCT03291821 - DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore | Biotech Hunter | Biotech Hunter