A Study to Evaluate the Efficacy and Safety of Semorinemab in Patients With Prodromal to Mild Alzheimer's Disease

PHASE2TerminatedINTERVENTIONAL
Enrollment

457

Participants

Timeline

Start Date

October 4, 2017

Primary Completion Date

January 15, 2021

Study Completion Date

January 15, 2021

Conditions
Alzheimer's Disease
Interventions
DRUG

Semorinemab

Participants will receive Semorinemab intravenously (IV).

DRUG

Placebo

Matching placebo doses of Semorinemab given intravenously (IV).

DRUG

[18F]GTP1

\[18F\]GTP1 will be administered as a solution for intravenous (IV) use, as part of positron emission tomography (PET) imaging.

Trial Locations (133)

1090

UZ Brussel, Brussels

2006

Hospital Perpetuo Socorro, Servicio de Geriatria, Albacete

2010

St Vincents Medical Centre, Darlinghurst

2217

Southern Neurology, Kogarah

3000

UZ Leuven, Leuven

3004

The Alfred Hospital, Melbourne; Thrombosis and Haemostasis Unit, Melbourne

3050

Royal Melbourne Hospital, Parkville

3128

Eastern Clinical Research Unit; Pharmacy, Box Hill

3144

HammondCare Aged Psychiatry Clinical Trials, Malvern

3174

Neuro Trials Victoria, Noble Park

4218

Queensland University of Technology, Mermaid Waters

7100

CCBR - Vejle - DK, Vejle

8500

AZ Groeninge, Kortrijk

8800

AZ Delta Campus Westlaan, Roeselare

9000

Center For Clinical and Basic Research (Ccbr); Site Management Organisation, Aalborg

10032

Columbia Univ Medical Center, New York

10245

Praxis Dr. med. Volker Shumann, Berlin

10600

Hospital Virgen del Puerto, Plasencia

10626

Studienambulanz emovis GmbH; St. Joseph Krankenhaus, Berlin

12110

Empire Neurology PC; MS Center of Northeastern NY, Latham

12203

Charite Campus Benjamin Franklin, Berlin

12208

Albany Medical College; Neurology, Albany

13005

CHU de la Timone - Hopital d Adultes; Service de Neurologie, Marseille

13156

Neurologisch-psychiatrische Praxis am Brosepark, Berlin

14011

Hospital Universitario Reina Sofia; Servicio de Neurologia, Córdoba

14642

University of Rochester; AD-CARE, Rochester

16132

Azienda Ospedaliero Universitaria San Martino; Dip. di Neuroscienze Oftalmologia e Genetica, Genoa

19001

Abington Neurological Associates, Abington

20009

Policlinica Guipuzcoa, Donostia / San Sebastian

20057

Georgetown University Hospital, Washington D.C.

20133

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan

25125

IRCCS Centro San Giovanni di Dio FBF, Brescia

28034

Hospital Universitario Ramon y Cajal, Madrid

28049

Hospital de Cantoblanco; Servicio de Geriatria, Madrid

30159

Klinische Forschung Hannover-Mitte GmbH, Hanover

30322

Emory University; Global Health, Atlanta

31008

Clinica Universitaria de Navarra; Servicio de Neurología, Pamplona

31059

Hopital de La Grave, Toulouse

32806

Compass Research East, LLC, Orlando

33076

Groupe Hospitalier Pellegrin; Service de Neurologie - 3ème étage, Bordeaux

33137

Miami Jewish Health Systems, Miami

33407

Premiere Research Institute, West Palm Beach

33414

Alzheimer's Research and Treatment Center, Wellington

33445

Brain Matters Research, Inc., Delray Beach

33462

JEM Research LLC, Atlantis

33613

Stedman Clinical Trials, LLC, Tampa

33912

Neuropsychiatric Research; Center of Southwest Florida, Fort Myers

34105

Collier Neurologic Specialists, Naples

34205

Bradenton Research Center, Bradenton

34295

Hopital Gui de Chauliac; Neurologie, Montpellier

35033

CHU Rennes, Rennes

35249

University of Alabama at Birmingham, Birmingham

37920

New Orleans Center For Clinical Research, Knoxville

38018

Neurology Clinic PC, Cordova

39185

Länssjukhuset Kalmar; Oncology, Kalmar

41009

Hospital Universitario Virgen Macarena, Seville

46017

Hospital Universitario Dr. Peset; Servicio de Neurologia, Valencia

46026

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

48903

Hospital de Cruces; Servicio de Neurologia, Barakaldo

55130

Health Partners Institute for Education and Research, Saint Paul

57076

ZNS Siegen im MVZ Weidenau, Siegen

59037

Hopital Roger Salengro, Lille

60007

Alexian Brothers Neuroscience Institute, Elk Grove Village

60612

Rush Alzheimer's Disease Cntr., Chicago

62702

Southern Illinois University, School of Medicine, Springfield

67000

CHU Hautepierre; ACTR Association Recherche Clinique Rhumatologie, Strasbourg

67098

CHU Strasbourg - Hôpital Hautepierre, Strasbourg

69100

Hopital des Charpennes, Villeurbanne

69500

Hopital Neurologique Pierre Wertheimer, Bron

72076

Universitätsklinik Tübingen; Psychiatrie und Psychotherapie, Tübingen

73039

Az. Osp. C. Panico; Rep. Ematologia E Trapianto, Tricase - LE

75010

Hopital Fernand Widal Centre, Paris

75651

Groupe Hospitalier Pitie-Salpetriere, Paris

81675

Klinikum rechts der Isar der TU München; Klinik & Poliklinik für Neurologie, München

86077

IRCCS Neuromed; Neurologia I-Centro studio e cura delle demenze e UVA, Pozzilli

89081

Universitätsklinikum Ulm; Klinik für Neurologie, Ulm

89312

Bezirkskrankenhaus Günzburg, Günzburg

90404

Neurological Research Inst, Santa Monica

90502

Collaborative Neuroscience Network Inc., Torrance

91206

California Clinical Trials, Glendale

92103

Pacific Research Network - PRN, San Diego

92660

Pharmacology Research Inst, Newport Beach

92697

University of California Irvine, Irvine

94304

Stanford Neuroscience Health Center (SNHC), Palo Alto

95445

Klinikum Bayreuth; Krankenhaus Hohe Warte, Bayreuth

97210

Summit Research Network Inc., Portland

06510

Invicro, a Konica Minolta company, New Haven

Yale University, New Haven

06905

KI Health Partners, LLC; New England Institute for Clinical Research, Stamford

04401

Eastern Maine Medical Center, Bangor

02115

Brigham & Women's Hosp; TIMI Study Grp, Boston

02169

Alzheimers Disease Center, Quincy

07856

NeuroCognitive Institute, Mount Arlington

08755

Advanced Memory Research Institute of NJ, Toms River

02914

Rhode Island Mood & Memory Research Institute, East Providence

02906

Butler Hospital, Providence

05201

Clinical Neuroscience Research Associates, Inc., Bennington

L7M 1K9

JBN Medical Diagnostic Services; Clinical Trials Division, Burlington

N6C 0A7

Parkwood Institute, Mental Health Care Building, London

K1N 5C8

Elisabeth Bruyere Hospital, Ottawa

M3B 2S7

Toronto Memory Program, Toronto

M4G 3E8

Centre for Memory and Aging, Toronto

M4N 3M5

Toronto Sunnybrook Hospital, Toronto

M5T 2S8

Toronto Western Hospital, Toronto

J8T 8J1

Recherches Neuro-Hippocame, Gatineau

00185

Umberto I Policlinico di Roma-Università di Roma La Sapienza, Rome

00186

Ospedale San Giovanni Calibita Fatebenefratell;Neurologia, Rome

5223 GZ

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

1081 GN

Brain Research Center B.V, Amsterdam

15-756

Podlaskie Centrum Psychogeriatrii, Bialystok

85-796

PALLMED Sp. z o.o. prowadząca NZOZ DOM SUE RYDER, Bydgoszcz

40-595

M.A. - LEK A.M.Maciejowscy SC., Katowice

40-650

Novo-Med Zielinski i wspolnicy Sp. j., Katowice

30-510

Malopolskie Centrum Medyczne, Krakow

61-853

NEURO - KARD Ośrodek Badań Klinicznych, Poznan

41-100

NEURO-CARE Sp. z o.o. Sp. Komandytowa, Siemianowice Śląskie

81-855

Senior Sp. Z O.O. Poradnia Psychogeriatryczna, Sopot

70-11

EroMedis, Szczecin

01-518

AMED Medical Center, Warsaw

01-684

Centrum Medyczne NeuroProtect, Warsaw

53-659

NZOZ WCA, Wroclaw

08221

Hospital Mutua de Terrassa, Terrassa

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

08028

Fundación ACE; Servicio de Neurología, Barcelona

08036

Hospital Clinic i Provincial de Barcelona, Barcelona

551 85

Länssjukhuset Ryhov, Jönköping

212 24

Skane University Hospital Malmo/Lund, Dept.of Hematology and Coagulation Disorders, Malmo

S-431 80

Sahlgrenska Univ Hospital Mölndal; Department of Nephrology, Mölndal

171 64

Karolinska Universitetssjukhuset Huddinge, Stockholm

G20 0XA

Glasgow Memory Clinic, Glasgow

W1G 9RU

RE:Cognition Health, London

WC1N 3BG

The National Hospital for Neurology & Neurosurgery, London

GU2 7YD

Re:Cognition Health Guildford, Surrey

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY

NCT03289143 - A Study to Evaluate the Efficacy and Safety of Semorinemab in Patients With Prodromal to Mild Alzheimer's Disease | Biotech Hunter | Biotech Hunter