REduced Dose Versus Full-dose of Direct Oral Anticoagulant After uNprOvoked Venous thromboEmbolism.

PHASE3CompletedINTERVENTIONAL
Enrollment

2,774

Participants

Timeline

Start Date

November 2, 2017

Primary Completion Date

November 8, 2023

Study Completion Date

November 8, 2023

Conditions
Venous Thromboembolism
Interventions
DRUG

Reduced dose of DOAC

The patient will receive apixaban 2.5 mg twice daily or rivaroxaban 10 mg once daily during a mean follow-up period of 36 months (12 to 65 months)

DRUG

Full dose of DOAC

The patient will receive apixaban 5 mg twice daily or Rivaroxaban 20 mg once daily during a mean follow-up period of 36 months (12 to 65 months)

Trial Locations (39)

21079

CHU de Dijon, Dijon

22000

CH de Saint Brieuc - Hôpital Yves Le Foll, Saint-Brieuc

24019

CH de Périgueux, Périgueux

25000

CHU de Besançon - Hôpital Jean Minjoz, Besançon

29107

CH de Quimper, Quimper

29240

HIA Brest, Brest

29609

CHRU de Brest, Brest

31059

CHU de Toulouse - Hôpital de Rangueil, Toulouse

33075

CH Bordeaux, Bordeaux

34170

Clinique de Clapiers, Castelnau-le-Lez

34830

Cabinet médical, Clapiers

35203

CHU de Rennes - Hôpital Sud, Rennes

37170

CHU de Tours - Hôpital Trousseau, Tours

38700

CHU de Grenoble - Hôpital Nord Michallon, Grenoble

42055

CHU de Saint Etienne - Hôpital Nord, Saint-Etienne

44000

CHU de Nantes, Nantes

45100

CHR Orléans, Orléans

54511

Chru Nancy, Nancy

62022

CH d'Arras, Arras

63003

CHU de Clermont Ferrand - Hôpital Gabriel Montpied, Clermont-Ferrand

75014

Hôpital de Cochin, Paris

75015

HEGP, Paris

75018

CHU Paris Nord Val de Seine, Paris

76000

CHU de ROUEN, Rouen

76290

GH Le Havre, Le Havre

80054

CHU Amiens-Picardie, Amiens

83056

CH de Toulon - Hôpital Sainte-Musse, Toulon

83800

HIA Sainte-Anne, Toulon

87042

CHU de Limoges - Hôpital de Dupuytren, Limoges

92141

HIA Percy, Clamart

92700

APHP Hôpital Louis Mourier, Colombes

Unknown

CHU Angers, Angers

HEGP, Paris

Kremlin Bicêtre, Paris

72 000

CH Le Mans, Le Mans

29 672

CH Morlaix, Morlaix

06002

CHU de Nice - Hôpital Pasteur, Nice

30 029

CHU Nîmes, Nîmes

59 322

CH Valenciennes, Valenciennes

All Listed Sponsors
collaborator

University Hospital of Saint-Etienne

OTHER

lead

University Hospital, Brest

OTHER

NCT03285438 - REduced Dose Versus Full-dose of Direct Oral Anticoagulant After uNprOvoked Venous thromboEmbolism. | Biotech Hunter | Biotech Hunter