Evaluation of Atezolizumab-Venetoclax-Obinutuzumab Combination in Relapse/Refractory Lymphomas

PHASE2CompletedINTERVENTIONAL
Enrollment

136

Participants

Timeline

Start Date

February 12, 2018

Primary Completion Date

September 19, 2019

Study Completion Date

August 24, 2022

Conditions
Follicular LymphomaDiffuse Large B Cell LymphomaMarginal Zone LymphomaMucosa Associated Lymphoid Tissue
Interventions
DRUG

Atezolizumab

1200 mg on day 2 of each 21-day cycle during 18 months (24 cycles)

DRUG

Obinutuzumab

1000 mg on day 1, day 8 and day 15 of cycle 1 and each day 1 from cycle 2 to cycle 8

DRUG

Venetoclax

800 mg/d from day 8 of cycle 1, every day during 18 months. For MZL patients wiht lymphocytes\>5 g/l : 50 mg/day: week 1 100mg/day: week 2 200mg/day: week 3 400mg/day: week 4 800mg/day: from week 5

Trial Locations (25)

13273

Institut Paoli Calmettes, Marseille

14000

CHU de Caen, Caen

21000

CHU de Dijon, Dijon

31100

Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse

34295

CHU de Montpellier, Montpellier

35003

CHU de Rennes - Hôpital de Pontchaillou, Rennes

37044

CHRU de Tours, Tours

38700

CHU de Grenoble, La Tronche

44093

CHU de Nantes, Nantes

49933

CHU d'Angers, Angers

54511

CHU de Nancy - Brabois, Nancy

59037

CHRU de Lille, Lille

62000

CHU de Nice, Nice

63000

CHU de Clermont Ferrand - Estaing, Clermont-Ferrand

67100

CHRU de Strasbourg, Strasbourg

69373

Centre Léon Bérard, Lyon

69495

CHU Lyon Sud, Pierre-Bénite

74370

CH Annecy Gennevois, Épagny

75010

Hôpital Saint Louis, Paris

75015

Hôpital Necker, Paris

76038

Centre Henri Becquerel, Rouen

85925

CHD de Vendée, La Roche-sur-Yon

86021

CHU de Poitiers, Poitiers

92210

Institut Curie - Hôpital René Huguenin, Saint-Cloud

94010

Hopital Henri Mondor, Créteil

All Listed Sponsors
lead

The Lymphoma Academic Research Organisation

OTHER

NCT03276468 - Evaluation of Atezolizumab-Venetoclax-Obinutuzumab Combination in Relapse/Refractory Lymphomas | Biotech Hunter | Biotech Hunter