1,000
Participants
Start Date
November 16, 2017
Primary Completion Date
July 5, 2026
Study Completion Date
July 5, 2026
Polatuzumab Vedotin
Polatuzumab vedotin IV infusion will be administered as per the schedule specified in the respective arm.
Rituximab
Rituximab IV infusion will be administered as per the schedule specified in the respective arm.
Cyclophosphamide
Cyclophosphamide IV infusion will be administered as per the schedule specified in the respective arm.
Doxorubicin
Doxorubicin IV infusion will be administered as per the schedule specified in the respective arm.
Vincristine
Vincristine IV infusion will be administered as per the schedule specified in the respective arm.
Vincristine Placebo
Placebo matching to vincristine will be administered as per the schedule specified in the respective arm.
Prednisone
Prednisone PO will be administered as per the schedule specified in the respective arm.
Polatuzumab vedotin Placebo
Placebo matching to polatuzumab vedotin will be administered as per the schedule specified in the respective arm.
Chi-Mei Hospital, Liouying, Tainan City
Kaohsiung Medical University Hospital, Cancer Center, Kaohsiung City
Auckland City Hospital, Cancer and Blood Research, Auckland
Medizinische Universität Wien, Vienna
Wiener Gesundheitsverbund ? Klinik Ottakring, Vienna
Prince of Wales Hospital, Randwick
Concord Repatriation General Hospital, Concord
Westmead Hospital, Westmead
St George Hospital, Kigarah
Calvary Mater Newcastle, Waratah
Austin Hospital, Heidelberg
Monash Medical Centre, Clayton
Waikato Hospital, Hamilton
Universitätsspital Basel Gynäkologie - Onkologie, Basel
Princess Alexandra Hospital Woolloongabba, Woolloongabba
The University of Adelaide - The Queen Elizabeth Hospital (TQEH), Woodville South
Paracelsus Medizinischen Privatuniversitaet-Salzburger Landeskliniken (SALK), Salzburg
Ashford Cancer Center Research, Kurralta Park
CHU UCL Mont-Godinne, Mont-godinne
CH Jolimont - Lobbes (Jolimont), Haine-Saint-Paul
Canterbury Health Laboratories, Christchurch
UZ Gent, Ghent
National Taiwan University Hospital, Taipei
Hospital San Pedro de Alcantara, Cáceres
New York University Cancer Cen, New York
Memorial Sloan Kettering Cancer Center, New York
Memorial Sloan Kettering Cancer Center at Westchester, Harrison
Vivantes Klinikum Am Urban, Berlin
Taipei Veterans General Hospital, Taipei
Memorial Sloan Kettering Cancer Center - Commack, Commack
Institut d'Hématologie de Basse Normandie, Caen
Roswell Park Cancer Institute, Buffalo
University of Rochester Medical Center, Rochester
University of Pittsburgh Medical Center Cancer Center, Pittsburgh
IRCCS AOU San Martino - IST, Genoa
Hospital Universitari Dr. Josep Trueta, Girona
Hospital of the University of Pennsylvania, Philadelphia
Fox Chase Cancer Center, Philadelphia
Georgetown University Medical Center, Washington D.C.
Istituto Nazionale dei Tumori, Monza
CHU de Dijon - Hopital le Bocage, Dijon
University of Maryland, Baltimore
Johns Hopkins University, Baltimore
Centre Hospitalier de Saint Brieuc - Hôpital Yves Le Foll, Saint-Brieuc
Virginia Cancer Specialists, PC, Fairfax
Oncology Associates of Southwest Virginia, Inc., Blacksburg
Azienda Ospedaliera Papa Giovanni XXIII, Bergamo
Hopital Jean Minjoz, Besançon
West Virginia Uni Med. Center - Robert Byrd Health Science, Morgantown
University of North Carolina at Chapel Hill, Chapel Hill
Fundación Jimenez Díaz, Madrid
Azienda Ospedaliero Universitaria Maggiore della Carita di Novara, Novara
Levine Cancer Institute - Clincal Trials Administration, Charlotte
Hospital Quiron Madrid, Madrid
Khmelnytskyi Regional Hospital, Khmelnytskyi
Hospital Universitario Virgen de la Victoria, Málaga
Centre Hospitalier de Quimper Cornouaille (CHIC), Quimper
Medical University of South Carolina Hospital, Charleston
Prisma Health ? Upstate, Greenville
CHU de Nîmes - Hôpital Carémeau, Nîmes
Emory University, Atlanta
Complejo Hospitalario de Navarra, Pamplona
Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O), Toulouse
Institut Bergonie, Bordeaux
Florida Cancer Specialists, West Palm Beach
Hopital Haut-Leveque - Centre Francois Magendie, Pessac
Florida Cancer Specialists & Research Institute, St. Petersburg
CHU Montpellier - Saint ELOI, Montpellier
Hopital Pontchaillou, Rennes
Ege Üniversitesi Tip Fakültesi, Lzmir
University of Alabama at Birmingham, Birmingham
Dokuz Eylul Universitesi Tip Fakultesi, Lzmir
Southern Cancer Center, Daphne
CHU Bretonneau, Tours
Tennessee Oncology - Nashville, Nashville
Greco-Hainesworth Centers for Research, Chattanooga
L'Union Mutualiste de la Gestion des Eaux Claires - Institut Daniel Hollard, Grenoble
Hôpital Albert Michallon, La Tronche
University of Louisville Hospital, Louisville
China Medical University Hospital, Taichung
Hospital Universitario Virgen del Rocio, Seville
Pôle de Cancérologie ? CHU de Saint?Etienne', Saint-Priest-en-Jarez
Ohio State University, Columbus
CHU de Nantes - Hotel Dieu, Nantes
University Hospitals Case Medical Center, Cleveland
Universitätsklinikum Essen, Essen
Oncology/Hematology Care Clinical Trials LLC, Cincinnati
University of Michigan Health System, Ann Arbor
Universitatsklinikum Munster, Münster
Karmanos Cancer Center, Detroit
Pusan National University Hospital, Busan
CHU Angers, Angers
CHU de Brabois, Vandœuvre-lès-Nancy
CH Bretagne Atlantique, Vannes
InVO - Institut für Versorgungsforschung in der Onkologie GbR, Koblenz
Hôpital Saint Vincent de Paul, Lille
Hopital Claude Huriez, Lille
Illinois Cancer Specialists, Arlington Heights
Washington University, St Louis
Centre Hospitalier de La Cote Basque, Bayonne
Hopital Saint Jean, Perpignan
Chru de Strasbourg, Strasbourg
Centre Leon Berard, Lyon
Universitaetsklinikum Heidelberg, Heidelberg
CHU Lyon Sud - Service Hématologie, Pierre-Bénite
Ochsner Medical Center, New Orleans
Clinique Victor Hugo - Centre Jean Bernard, Le Mans
CH Metropole de Savoie, Chambéry
Hôpital Saint-Louis, Paris
Texas Oncology-Tyler, Tyler
Gh Necker Enfants Malades, Paris
Centre Henri Becquerel, Rouen
Texas Oncology San Antonio Medical Center, San Antonio
Texas Oncology-Austin Midtown, Austin
MNE Lviv Territorial Medical Association Clinical Hospital for Palliative Care, Lviv
Rocky Mountain Cancer Centers, LLP, Aurora
CHU Amiens - Hopital Sud, Amiens
University of Utah, Salt Lake City
CHD Vendée, La Roche-sur-Yon
CHU de Poitiers, Poitiers
Hopital Uni Ire Dupuytren, Limoges
Ronald Reagan UCLA Medical Center, Los Angeles
City of Hope, Duarte
Hopital Henri Mondor, Créteil
Institut Gustave Roussy, Villejuif
Northwest Cancer Specialists - Portland (SW Barnes Rd), Portland
Oregon HSU, Portland
Oncology Associates of Oregon, P.C, Eugene
Seattle Cancer Care Alliance, Seattle
Beijing Cancer Hospital, Beijing
The First Hospital of Jilin University, Changchun
Leningrad Regional Clinical Hospital, Saint Petersburg
Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Shanghai East Hospital, Tongji University, Shanghai
Jiangsu Cancer Hospital, Nanjing
Hospital Universitario La Paz, Madrid
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences, Tianjin
Tianjin Medical University Cancer Institute & Hospital, Tianjing
The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou
Fujian Provincial Cancer Hospital, Fuzhou
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan
Henan Cancer Hospital, Zhengzhou
Sun Yet-sen University Cancer Center, Guangzhou
Florida Cancer Specialists - Fort Myers (New Hampshire Ct), Fort Myers
Massachusetts General Hospital, Boston
Dana Farber Cancer Institute, Boston
Memorial Sloan Kettering Bergen, Montvale
Hospital Erasto Gaertner, Curitiba
Hospital das Clinicas - UFRGS, Porto Alegre
Universita degli Studi Di Brescia - Azienda Ospedaliera Spedali Civili di Brescia, Brescia
"Universita degli Studi di Roma ''La Sapienza - Clinica Ematologica", Rome
AUSL di Reggio Emilia, IRCCS, P.O. Arcispedale Santa Maria Nuova, Reggio Emilia
Pusan National University Yangsan Hospital, Yangsan
Communal Institution 'Cherkassy Regional Oncology Dispensary' of the Cherkassy Regional Council, Cherkassy
Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP, Campinas
Hospital das Clinicas - FMUSP, São Paulo
University of Alberta Hospital, Edmonton
BC Cancer ? Vancouver, Vancouver
CancerCare Manitoba (CCMB), Winnipeg
The Ottawa Hospital, Ottawa
Sunnybrook Health Sciences Centre, Toronto
CIUSSS de l Est de l Ile de Montreal - Hopital Maisonneuve Rosemont, Montreal
CHU de Quebec-Universite Laval, Québec
Fakultni Nemocnice Hradec Kralove (FNHK), Hradec Králové
Fakultni nemocnice Olomouc, Olomouc
Fakultni nemocnice Ostrava, Ostrava - Poruba
Fakultni Nemocnice Kralovske Vinohrady (FNKV), Prague
Všeobecná fakultní nemocnice v Praze, Prague
Centre Antoine Lacassagne, Nice
Städtisches Klinikum Dessau, Dessau
Universitaetsklinikum Halle (Saale), Halle
Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino, Turin
Aichi Cancer Center, Aichi
Chiba Cancer Center, Chiba
National Cancer Center Hospital East, Chiba
Chiba University Hospital, Chūōku
National Hospital Organization Kyushu Cancer Center, Fukuoka
Kyushu University Hospital, Fukuoka
Hiroshima University Hospital, Hiroshima
Hokkaido University Hospital, Hokkaido
Kobe City Medical Center General Hospital, Hyōgo
Tokai University Hospital, Isehara-shi
Kumamoto University Hospital, Kumamoto
University Hospital Kyoto Prefectural University of Medicine, Kyoto
Tohoku University Hospital, Miyagi
Osaka Metropolitan University Hospital, Osaka
The University of Osaka Hospital, Osaka
Kindai University Hospital, Osaka
Jichi Medical University Hospital, Tochigi
National Cancer Center Hospital, Tokyo
The Cancer Institute Hospital of JFCR, Tokyo
Wojewódzki Szpital Specjalistyczny im. M. Kopernika, ?ód?
Samodzielny Publiczny Zak?ad Opieki Zdrowotnej Zespó? Szpitali Miejskich w Chorzowie, Chorzów
PRATIA MCM Kraków, Krakow
SPZOZ Ministerstwa Spraw Wewn?trznych i Administracji w Poznaniu, Późna
Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy, Warsaw
National Cancer Center, Gyeonggi-do
Seoul National University Hospital, Seoul
Severance Hospital, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clinic Barcelona, Barcelona
Hospital de la Santa Creu i Sant Pau, Barcelona
Institut Catala d Oncologia Hospitalet, Barcelona
Ankara University Faculty of Medicine Cebeci Hospital, Ankara
Feofaniya Center of Haematology and Chemotherapy of Haemoblastosis, Kyiv
Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital, Cambridge
East Kent Hospitals University NHS Foundation Trust, Canterbury
University Hospitals of Leicester NHS Trust - Leicester Royal Infirmary, Leicester
Barts Health NHS Trust, London
The Christie NHS Foundation Trust, Manchester
The Newcastle upon Tyne Hospitals NHS Foundation Trust. Freeman Hospital, Newcastle upon Tyne
Nottingham City Hospital, Nottingham
Oxford University Hospitals NHS Foundation Trust, Oxford
Hoffmann-La Roche
INDUSTRY