30
Participants
Start Date
September 7, 2017
Primary Completion Date
October 10, 2018
Study Completion Date
October 10, 2018
Written Informed Consent
To be completed prior to conducting any study related procedures
Inclusion/Exclusion check
Eligibility check
Full Clinical Chemistry and Haematology Bloods
Participant required to fast for at least 6-8 hoursprior to visit. (Clear, non-caffeinated fluids are allowed)
Serum sample for systemic markers and lipid sub-fractions
Serum samples may be stored for later analysis.
Pregnancy Test
If applicable for women of child bearing potential
12 Lead ECG
participant resting supine
Blood Pressure and Heart Rate
Measured in the seated position after 5 minutes rest
Arterial Stiffness
Measure of functional and structural changes which accompanies cardiovascular disease
Central Haemodynamics
Measure of functional and structural changes which accompanies cardiovascular disease
Carotid Intima Media Thickness
Measurements will be repeated three times, and the average of the median values will be recorded
Forearm blood flow studies
Assess and determine vascular function, which can interrogate endothelium dependent and independent mechanisms of nitric oxide bioavailability
Concomitant medication check
Review of medication taken by the participant
Medication compliance check (Pill count)
Ensure prescribed statin has been taken
Physical examination
Check overall health
Medical history
Review of volunteers medial history
AE/SAE review & reporting
Monitor safety from the point of consent
Dosing
To be performed at the end of the visit following completion all other study visits
Addenbrooke's Hospital, Cambridge
University of Cambridge
OTHER
Cambridge University Hospitals NHS Foundation Trust
OTHER