Islatravir (MK-8591) With Doravirine and Lamivudine in Participants Infected With Human Immunodeficiency Virus Type 1 (MK-8591-011)

PHASE2CompletedINTERVENTIONAL
Enrollment

123

Participants

Timeline

Start Date

November 27, 2017

Primary Completion Date

March 8, 2021

Study Completion Date

March 9, 2022

Conditions
HIV-1 Infection
Interventions
DRUG

Islatravir

Islatravir at 0.25 mg, 0.75 mg or 2.25 mg is orally administered QD in capsule form for up to 52 weeks. After Week 60 a selected open label dose may be administered.

DRUG

Placebo to Islatravir

Placebo to islatravir is orally administered QD in capsule form for up to 52 weeks

DRUG

Doravirine

Doravirine 100 mg is orally administered QD in tablet form for up to 144 weeks

DRUG

Placebo to Doravirine

Placebo to Doravirine is orally administered QD in tablet form for up to 52 weeks

DRUG

Lamivudine

Lamivudine 300 mg is orally administered QD in tablet form for up to 52 weeks

DRUG

Placebo to Lamivudine

Placebo to Lamivudine is orally administered QD in tablet form for up to 52 weeks

DRUG

Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate

Fixed dose combination of 100 mg doravirine + 300 mg lamivudine + 300 mg tenofovir disoproxil fumarate is orally administered QD in tablet form for up to 144 weeks.

DRUG

Placebo to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate

Placebo to doravirine/lamivudine/tenofovir disoproxil fumarate is orally administered QD in tablet form for up to 52 weeks

DRUG

Doravirine/Islatravir

Fixed dose combination of islatravir 0.75 mg/doravirine 100 mg orally administered QD in tablet form for 48 weeks

Trial Locations (26)

20005

Whitman Walker Clinic ( Site 0108), Washington D.C.

32803

Orlando Immunology Center (OIC) ( Site 0105), Orlando

60657

Northstar Medical Center ( Site 0102), Chicago

64111

Kansas City CARE Clinic ( Site 0106), Kansas City

75246

North Texas Infectious Diseases Consultants, PA ( Site 0103), Dallas

76104

Tarrant County Infectious Disease Associates ( Site 0112), Fort Worth

77098

The Crofoot Research Center, Inc. ( Site 0118), Houston

77401

Saint Hope Foundation, Inc. ( Site 0116), Bellaire

85015

Pueblo Family Physicians ( Site 0119), Phoenix

95817

University California / Davis ( Site 0101), Sacramento

Unknown

Clinica Arauco Salud ( Site 0200), Santiago

Biomedica Research Group ( Site 0202), Santiago

Hospital Dr. Hernan Henriquez Aravena ( Site 0203), Temuco

Hopital Avicenne ( Site 2302), Bobigny

Hopital Saint-Andre ( Site 2307), Bordeaux

CHU Hotel Dieu ( Site 2308), Nantes

CHU de Nice Hopital Archet 1 ( Site 2303), Nice

Hopital Bichat - Claude Bernard ( Site 2309), Paris

Hopital Pitie Salpetriere ( Site 2305), Paris

Hopital Saint Louis ( Site 2306), Paris

Centre Hospitalier de Tourcoing ( Site 2301), Tourcoing

Brighton and Sussex University Hospitals NHS Trust ( Site 2105), Brighton

Chelsea and Westminster Hospital ( Site 2101), London

Royal London Hospital ( Site 2103), London

The Royal Free London NHS Foundation Trust ( Site 2102), London

North Manchester General Hospital ( Site 2104), Manchester

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03272347 - Islatravir (MK-8591) With Doravirine and Lamivudine in Participants Infected With Human Immunodeficiency Virus Type 1 (MK-8591-011) | Biotech Hunter | Biotech Hunter