Study of Binimetinib + Nivolumab Plus or Minus Ipilimumab in Patients With Previously Treated Microsatellite-stable (MSS) Metastatic Colorectal Cancer With RAS Mutation

PHASE2CompletedINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

October 18, 2017

Primary Completion Date

October 13, 2020

Study Completion Date

February 25, 2021

Conditions
MSSRAS-mutant Colorectal Cancer
Interventions
DRUG

binimetinib

Orally, twice daily.

DRUG

nivolumab

Intravenously (IV) every 4 weeks (Q4W)

DRUG

ipilimumab

intravenously (IV) every 8 weeks (Q8W)

Trial Locations (50)

3000

UZ Leuven - Dermatology, Leuven

UZ Leuven - Ophthalmology, Leuven

UZ Leuven, Leuven

19104

Hospital of the University of Pennsylvania, Philadelphia

Investigational Drug Service of the University of Pennsylvania, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19713

Christiana Care Health Services, Helen F. Graham Cancer Center Pharmacy, Suite 3200, Newark

Christiana Care Health Services, Helen F. Graham Cancer Center, Newark

Christiana Care Oncology Hematology, Helen F Graham Cancer Center, Suite 2400, Newark

Medical Oncology Hematology Consultants, PA, Helen F. Graham Cancer Center, Newark

19718

Christiana Care Health Services, Christiana Hospital, Newark

20007

Georgetown University Medical Center Department of Pharmacy, Research, Washington D.C.

Georgetown University Medical Center, Washington D.C.

28007

Hospital General Universitario Gregorio Marañon, Madrid

28010

Clinica Rementeria, Madrid

28041

Hospital Universitario 12 Octubre, Madrid

28050

Hospital HM Universitario Sanchinarro, CIOCC, Madrid

34952

Hematology Oncology Associates of the Treasure Coast, Port Saint Lucie

37203

Tennessee Oncology NASH - SCRI - PPDS, Nashville

The Sarah Cannon Research Institute., Nashville

37311

Tennessee Oncology, PLLC, Cleveland

37404

Sarah Cannon Research Institute, Chattanooga

SCRI Tennessee Oncology Chattanooga, Chattanooga

46202

Indiana CTSI Clinical Research Center (ICRC), Indianapolis

Indiana University Health Hospital, Indianapolis

Indiana University Health Melvin and Bren Simon Cancer Center, Indianapolis

Investigational Drug Services IUHSCC, Indianapolis

Sidney &Lois Eskenazi Hospital, Indianapolis

46290

Spring Mill Medical Center, Indianapolis

63031

Siteman Cancer Center - North County, Florissant

63108

Center for Outpatient Health (Dermatology Clinic), St Louis

Center for Outpatient Health (Ophthalmology Clinic), St Louis

63110

Barnes-Jewish Hospital, St Louis

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center - South County, St Louis

63141

Siteman Cancer Center - West County, Creve Coeur

63376

Siteman Cancer Center - Barnes St. Peters, City of Saint Peters

77030

The University of Texas MD Anderson Cancer Center, Houston

90095

UCLA Hematology/Oncology, Los Angeles

90404

UCLA Hematology/Oncology - Santa Monica, Santa Monica

1066 CX

The Netherlands Cancer Institute Antoni Van Leeuwenhoek, Amsterdam

1091 AC

OLVG locatie Oost, Amsterdam

1105 AZ

Amsterdam Medical Center (AMC), Amsterdam

08035

Hospital Universitario Vall d'Hebron, Barcelona

Hospital Universitario Vall d'Hebrón - PPDS, Barcelona

SW3 6JJ

Royal Marsden Hospital - London, London

Royal Marsden Hospital NHS Foundation Trust, London

OX3 7LE

Churchill Hospital, Oxford

SM2 5PT

Royal Marsden Hospital NHS Foundation Trust, Surrey

SW36JJ

Royal Marsden Hospital -Fulham Road, London

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Pfizer

INDUSTRY