Does Cefoxitin or Piperacillin-Tazobactam Prevent Postoperative Surgical Site Infections After Pancreatoduodenectomy?

PHASE3CompletedINTERVENTIONAL
Enrollment

967

Participants

Timeline

Start Date

November 21, 2017

Primary Completion Date

January 28, 2025

Study Completion Date

January 28, 2025

Conditions
Pancreatic CancerPancreas CancerPancreatic Diseases
Interventions
DRUG

Cefoxitin

Participants will receive one dose of cefoxitin within 1 hour of incision time, redosed every 2-4 hours in the operating room until closure of the incision, and discontinued within 24 hours after anesthesia end time.

DRUG

Piperacillin-tazobactam

Participants will receive one dose of piperacillin-tazobactam within 1 hour of incision time, redosed every 2-4 hours in the operating room until closure of the incision, and discontinued within 24 hours after anesthesia end time.

Trial Locations (32)

10029

Mount Sinai Hospital, New York

Mount Sinai West, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10467

Montefiore Health Systems (Montefiore Medical Center), The Bronx

10604

Memoral Sloan Kettering Westchester (Consent only), Harrison

11725

Memorial Sloan Kettering Commack (Consent only), Commack

17033

Pennsylvania State Hershey, Hershey

19107

Thomas Jefferson University Hospital, Philadelphia

27713

Duke University, Durham

27834

Brody School of Medicine at East Carolina University, Greenville

30322

Emory University School of Medicine, Atlanta

38120

Baptist Memorial Healthcare, Memphis

43210

Ohio State University, Columbus

46202

Indiana University, Indianapolis

52242

University of Iowa, Iowa City

53792

University of Wisconsin, Madison

54601

Gundersen Lutheran Medical Foundation, La Crosse

60201

NorthShore University Health System, Evanston

60611

Northwestern Medicine (Data Collection), Chicago

63110

University of Washington School of Medicine, St Louis

75246

Baylor Scott & White Health, Dallas

84107

Intermountain Healthcare, Murray

84112

University of Utah, Salt Lake City

95817

UC Davis Comprehensive Cancer Center, Sacramento

97213

Providence Health & Services (Portland Med Ctr), Portland

02114

Massachusetts General Hospital, Boston

68198-7680

University of Nebraska Medical Center, Omaha

07920

Memorial Sloan Kettering Basking Ridge (Consent only), Basking Ridge

07601

Hackensack Meridian Health / Hackensack University Medical Center Cancer Center, Hackensack

Unknown

Hamilton Health Sciences Center (Juravinski Hospital), Hamilton

K1H 8L6

Ottawa Hospital, Ottawa

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

All Listed Sponsors
collaborator

Indiana University

OTHER

collaborator

Massachusetts General Hospital

OTHER

collaborator

Thomas Jefferson University

OTHER

collaborator

Washington University School of Medicine

OTHER

collaborator

Advocate Illinois Masonic Medical Center

OTHER

collaborator

Baptist Memorial Health Care Corporation

OTHER

collaborator

Baylor Scott and White Health

OTHER

collaborator

The Cleveland Clinic

OTHER

collaborator

Emory University

OTHER

collaborator

Fox Chase Cancer Center

OTHER

collaborator

Gundersen Lutheran Medical Center

UNKNOWN

collaborator

Hackensack Meridian Health

OTHER

collaborator

Hamilton Health Sciences Center

UNKNOWN

collaborator

Intermountain Health Care, Inc.

OTHER

collaborator

Jersey Shore Medical Center (Hackensack Meridian)

UNKNOWN

collaborator

Johns Hopkins University

OTHER

collaborator

Montefiore Medical Center/Albert Einstein College of Medicine

UNKNOWN

collaborator

North Shore University HealthSystem

UNKNOWN

collaborator

Milton S. Hershey Medical Center

OTHER

collaborator

Rhode Island Hospital

OTHER

collaborator

Stony Brook Medicine

UNKNOWN

collaborator

Sunnybrook Health Sciences Centre, Canada

UNKNOWN

collaborator

Temple University

OTHER

collaborator

Ohio State University

OTHER

collaborator

The Ottowa Hospital/University of Ottowa

UNKNOWN

collaborator

University of California, Davis

OTHER

collaborator

University of Chicago

OTHER

collaborator

University of Iowa

OTHER

collaborator

University of Texas Southwestern Medical Center

OTHER

collaborator

University of Utah

OTHER

collaborator

University of Wisconsin, Madison

OTHER

collaborator

Providence Health & Services

OTHER

collaborator

Albany Medical College

OTHER

collaborator

Northwestern University

OTHER

collaborator

Universtiy of Mississippi Medical Center

UNKNOWN

collaborator

Mount Sinai Hospital, New York

OTHER

collaborator

Brody School of Medicine at East Carolina University

UNKNOWN

lead

Memorial Sloan Kettering Cancer Center

OTHER