VX15/2503 in Combination With Avelumab in Advanced Non-small Cell Lung Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

October 5, 2017

Primary Completion Date

September 9, 2020

Study Completion Date

September 10, 2020

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

VX15/2503 + avelumab

Dose escalation will begin at 5 mg/kg of VX15/2503 and will increase up to 20 mg/kg with a constant dose of avelumab at 10 mg/kg. A recommended phase II dose of VX15/2503 will be determined and then utilized in the expansion phase with 10 mg/kg of avelumab.

Trial Locations (11)

11042

Northwell Health Cancer Institute, Lake Success

14604

University of Rochester, Rochester

22031

Virginia Cancer Specialists, PC, Fairfax

32224

Mayo Clinic, Jacksonville

33612

Moffitt Cancer Center, Tampa

44718

Gabrail Cancer Center, Canton

55905

Mayo Clinic, Rochester

63110

Washington University School of Medicine, St Louis

72703

Highlands Oncology Group, PA, Fayetteville

90095

University of California Los Angeles (UCLA), Los Angeles

97213

Providence Portland Medical Center, Portland

All Listed Sponsors
collaborator

Merck KGaA, Darmstadt, Germany

INDUSTRY

lead

Vaccinex Inc.

INDUSTRY

NCT03268057 - VX15/2503 in Combination With Avelumab in Advanced Non-small Cell Lung Cancer | Biotech Hunter | Biotech Hunter