Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes

PHASE4RecruitingINTERVENTIONAL
Enrollment

11,414

Participants

Timeline

Start Date

February 1, 2018

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2025

Conditions
Diabetes Mellitus, Type 2Adverse EventBlood PressurePrehypertensionCardiovascular Risk Factor
Interventions
DRUG

Allisartan Isoproxil

Allisartan Isoproxil 240mg daily will be used to lower BP to below 120 mm Hg systolic.

DRUG

Amlodipine 5mg

Amlodipine 5mg daily will be added to Allisartan Isoproxil and afterwards increased to 10mg daily, if necessary to reach the blood pressure goal (below 120 mm Hg systolic).

OTHER

Standard treatment by current guideline

No BP-lowering medications are used until BP becomes ≥ 140 mm Hg systolic and/or 90 mm Hg diastolic. Medications are determined by investigators in lines with recommendations by current Chinese guidelines to decrease BP to lower than 140 mm Hg systolic and to lower than 90 mm Hg diastolic.

Trial Locations (1)

501080

RECRUITING

Guangdong General Hospital, Guangzhou

All Listed Sponsors
lead

XueQing Yu

OTHER