Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care in mRCC (KEYNOTE-679/ECHO-302)

PHASE3CompletedINTERVENTIONAL
Enrollment

129

Participants

Timeline

Start Date

December 7, 2017

Primary Completion Date

August 22, 2018

Study Completion Date

June 4, 2025

Conditions
Renal Cell Carcinoma (RCC)
Interventions
DRUG

Pembrolizumab

Pembrolizumab 200 mg administered intravenously every 3 weeks.

DRUG

Epacadostat

Epacadostat 100 mg administered orally twice daily.

DRUG

Sunitinib

Sunitinib 50 mg administered orally once daily; 4 weeks on, 2 weeks off for 6-wk cycle.

DRUG

Pazopanib

Pazopanib 800 mg administered orally once daily.

Trial Locations (140)

112

Taipei Veterans General Hospital, Taipei

833

Chang Gung Med Foundation. Kaohsiung Branch, Kaohsiung City

1023

Auckland City Hospital, Auckland

1122

Orszagos Onkologiai Intezet, Budapest

1478

Akershus University Hospital, Lørenskog

1714

Sykehuset Oestfold, Grålum

2145

Westmead Hospital, Westmead

2298

Calvary Mater Newcastle, Waratah

2605

Canberra Hospital, Garran

3144

Cabrini Health, Malvern

3526

Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz, Miskolc

4615

Sorlandet sykehus HF, Kristiansand

5000

Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet, Szolnok

5053

Helse Bergen HF Haukeland sykehus, Bergen

6150

Fiona Stanley Hospital, Murdoch

7030

St Olavs Hospital, Trondheim

7400

Somogy Megyei Kaposi Mor Oktato Korhaz, Kaposvár

8900

Zala Megyei Szent Rafael Korhaz, Zalaegerszeg

9019

Universitetssykehuset i Nord Norge. Kreftavdelingen, Tromsø

9700

Markusovszky Egyetemi Oktatokorhaz, Szombathely

10048

National Taiwan University Hospital, Taipei

10065

Memorial Sloan Kettering Cancer Center, New York

12208

New York Oncology Hematology P.C, Albany

13125

Helios Klinikum Berlin Buch, Berlin

14076

Centre Francois Baclesse, Caen

15706

Hospital Clinico Universitario de Santiago, Santiago de Compostela

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

22601

Shenandoah Oncology, P.C., Winchester

24014

Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care, Roanoke

25030

CHU Besancon - Hopital Jean Minjoz, Besançon

25123

Azienda Ospedaliera-Spedali Civili, Brescia

27100

Policlinico San Matteo, Pavia

28007

Hospital General Universitario Gregorio Maranon, Madrid

28050

Hospital Universitario HM Sanchinarro, Madrid

28204

Levine Cancer Institute, Charlotte

30060

Northwest Georgia Oncology Centers Pc, Marietta

30094

Atlanta Cancer Care - Conyers, Conyers

30342

Northside Hospital, Atlanta

30625

Medizinische Hochschule Hannover, Hanover

32503

Woodlands Medical Specialists, PA, Pensacola

33075

Hopital Saint Andre, Bordeaux

34093

Istanbul Universitesi Onkoloji Enstitusu, Istanbul

34732

Istanbul Medeniyet Universitesi Goztepe EAH, Istanbul

35040

Ege Universitesi Tıp Fakultesi, Izmir

37403

University of Tennessee Erlanger Oncology & Hematology, Chattanooga

38138

The West Clinic, P.C., Germantown

39120

Universitaetsklinikum Magdeburg. Klinik fuer Urologie, Magdeburg

40022

RMI Sumy Regional Clinical Oncology Dispensary, Sumy

40447

China Medical University Hospital, Taichung

45147

Universitaetsklinikum Essen, Essen

46009

Instituto Valenciano de Oncologia, Valencia

49005

Dnipropetrovsk Regional Hospital n.a. I.I. Mechnikov, Dnipro

49102

Dnipropetrovsk City Multidiscipline Clinical Hosp. 4 of DRC, Dnipro

50048

MI Kryviy Rih Center of Dnipropetrovsk Regional Council, Kryvyi Rih

52100

Medical Oncology Ospedale San Donato, Arezzo

58128

Chonnam National University Hwasun Hospital, Hwasun

59100

Namik Kemal Universitesi Tip Fakultesi, Tekirdağ

60590

Universitaetsklinikum Frankfurt, Frankfurt am Main

60612

Rush University Medical Center, Chicago

67000

Clinique Sainte Anne, Strasbourg

67091

CHU de Strasbourg - Nouvel Hopital Civil, Strasbourg

68510

Southeast Nebraska Hematology & Oncology Consultants, P.C., Lincoln

69310

Hospices Civils de Lyon Centre Hospitalier Lyon Sud, Pierre-Bénite

70457

National Cheng Kung University Hospital, Tainan City

72076

Universitaetsklinikum Tuebingen, Tübingen

75015

Hopital Europeen Georges Pompidou, Paris

76018

MI Precarpathian Clinical Oncology Center, Ivano-Frankivsk

77380

US Oncology and Research, The Woodlands

80131

A.O. Cardarelli, Napoli

83400

Hopital Prive Toulon Hyeres Sainte Marguerite, Hyères

84106

Utah Cancer Specialists, Salt Lake City

84112

Huntsman Cancer Institute, Salt Lake City

85258

Pinnacle Oncology Hematology, Scottsdale

Scottsdale Healthcare, Scottsdale

85711

Arizona Oncology Associates PC- HOPE, Tucson

90048

Cedars-Sinai Medical Center, Los Angeles

92868

UC Irvine Comprehensive Cancer Center/Chao Family Comprehensive Cancer Center, Orange

94805

Institut Gustave Roussy, Villejuif

95817

UC Davis Comprehensive Cancer Center, Sacramento

97401

Willamette Valley Cancer Institute and Research Center, Eugene

117997

Russian Scientific Center of Roentgenoradiology, Moscow

121359

Central Clinical Hospital with outpatient Clinic, Moscow

125284

National Medical Research Radiology Centre, Moscow

153040

Ivanovo regional oncology dispensary, Ivanovo

188663

Leningrad Regional Oncology Dispensary, Saint Petersburg

450054

Republican Clinical Oncology Dispensary of Republic of Bashkortostan, Ufa

2520000

Hospital Clinico Vina del Mar, Viña del Mar

5311089

Clinica Alemana de Osorno, Osorno

7500921

Fundacion Arturo Lopez Perez FALP, Santiago

8320000

Pontificia Universidad Catolica de Chile, Santiago

30130090

Centro Avancado de Tratamento Oncologico - CENANTRON -, Belo Horizonte

02114

Massachusetts General Hospital, Boston

02215

Dana Farber Cancer Institute, Boston

90610-000

Centro de pesquisa Porto Alegre, Porto Alegre

14784-400

Fundacao Pio XII - Hospital de Cancer de Barretos, Barretos

01246-000

Instituto do Cancer de Sao Paulo - ICESP, São Paulo

01321-001

Hospital Sao Jose, São Paulo

90035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre

T2N 4N2

Tom Baker Cancer Centre, Calgary

K7L 2V7

Kingston Health Sciences Centre - KGH Site, Kingston

M4N 3M5

Sunnybrook Health Sciences, Odette Cancer Centre, Toronto

H3T 1E2

Jewish General Hospital, Montreal

G1R 2J6

CHU de Quebec-Universite Laval-Hotel Dieu de Quebec, Québec

G8Z 3R9

CIUSSS de la Mauricie-et-du-Centre-du-Quebec, Trois-Rivières

06189

Centre Antoine Lacassagne, Nice

01307

Universitaetsklinikum der Technischen Universitaet Dresden, Dresden

07747

Universitaetsklinikum Jena, Jena

00024

Adelaide & Meath Hospital, Dublin

X91ER8E

University Hospital Waterford, Waterford

00152

Azienda Ospedaliera San Camillo Forlanini, Roma

466-8560

Nagoya University Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

060-8543

Sapporo Medical University Hospital, Sapporo

060-8648

Hokkaido University Hospital, Sapporo

634-8522

Nara Medical University Hospital, Kashihara

589-8511

Kindai University Hospital, Sayama

350-1298

Saitama Medical University International Medical Center, Hidaka

755-8505

Yamaguchi University Hospital, Ube

010-8543

Akita University Hospital, Akita

812-8582

Kyushu University Hospital, Fukuoka

951-8520

Niigata University Medical & Dental Hospital, Niigata

105-8470

Toranomon Hospital, Tokyo

113-8603

Nippon Medical School Hospital, Tokyo

160-8582

Keio University Hospital, Tokyo

0450

Oslo universitetssykehus, Oslo

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08208

Hospital Parc Tauli, Sabadell

08003

Hospital del Mar, Barcelona

08916

Hospital Germans Trias i Pujol, Barcelona

01250

Baskent Universitesi Adana Dr. Turgut Noyan Uygulama ve Arastirma Merkezi, Adana

06100

Ankara Numune Education and Research Hospital, Ankara

Hacettepe University Medical Faculty, Ankara

SM2 5PT

The Royal Marsden NHS Foundation Trust., Sutton

EH4 2XU

Western General Hospital, Edinburgh

G12 0YN

Beatson Institute of Cancer Research, Glasgow

EC1A 7BE

Barts Health NHS Trust - St Bartholomew s Hospital, London

SW3 6JJ

The Royal Marsden Foundation Trust, London

MB204BX

The Christie NHS Foundation Trust, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Incyte Corporation

INDUSTRY

NCT03260894 - Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care in mRCC (KEYNOTE-679/ECHO-302) | Biotech Hunter | Biotech Hunter