A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

169

Participants

Timeline

Start Date

September 8, 2017

Primary Completion Date

May 10, 2022

Study Completion Date

May 10, 2022

Conditions
Advanced Solid Tumors
Interventions
DRUG

ASP8374

intravenous

DRUG

Pembrolizumab

intravenous

Trial Locations (54)

10032

Columbia University Medical Center, New York

15232

University of Pittsburgh Cancer Institute, Pittsburgh

19111

Fox Chase Cancer Center, Philadelphia

22031

Virginia Cancer Specialists, Fairfax

33140

Mount Sinai Comprehensive Cancer Center, Miami Beach

37203

Sarah Cannon Research Institute, Nashville

44106

University Hospital of Cleveland, Cleveland

48201

Karmanos Cancer Institute, Detroit

48202

Henry Ford Health System, Detroit

52242

University of Iowa Hospitals and Clinics, Iowa City

66205

University of Kansas Cancer Center, Fairway

75251

Mary Crowley Research Center, Dallas

84112

Huntsman Cancer Institute, Salt Lake City

85258

Honor Health Research Institute, Scottsdale

90048

Cedars-Sinai Medical Center, Los Angeles

90095

University of California Los Angeles, Los Angeles

94115

University of California, San Francisco, San Francisco

95817

University of California, Davis, Sacramento

53226-3522

Medical College of Wisconsin, Milwaukee

T6G 1Z2

Site CA15004, Edmonton

M4N 3M5

Site CA15003, Toronto

M5G 2M9

Site CA15001, Toronto

H3T 1E2

Site CA15002, Montreal

Unknown

Site IT39004, Ancona

Site IT39002, Milan

Site IT39003, Milan

Site IT39008, Milan

Site IT39009, Milan

Site IT39010, Modena

Site IT39005, Monza

Site IT39011, Negrar

Site JP81001, Chūōku

Site PT35101, Lisbon

Site PT35106, Porto

Site KR82006, Seoul

Site ES34002, Barcelona

Site ES34003, Barcelona

Site ES34009, Barcelona

Site ES34010, Barcelona

Site ES34001, Madrid

Site ES34006, Madrid

Site ES34013, Madrid

Site ES34014, Valencia

Site TW88601, Tainan City

Site TW88603, Taipei

Site GB44003, London

Site GB44006, London

Site GB44004, Newcastle upon Tyne

Site GB44005, Sutton Surry

410-769

Site KR82004, Goyang-si

013620

Site KR82005, Seongnam-si

03080

Site KR82001, Seoul

120-752

SIte KR82002, Seoul

00404

Site TW88602, Taichung

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Astellas Pharma Global Development, Inc.

INDUSTRY

NCT03260322 - A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter