Study Investigating the Efficacy of Crenolanib With Chemotherapy vs Chemotherapy Alone in R/R FLT3 Mutated AML

PHASE3UnknownINTERVENTIONAL
Enrollment

322

Participants

Timeline

Start Date

June 5, 2018

Primary Completion Date

October 31, 2024

Study Completion Date

October 31, 2024

Conditions
Relapsed/Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations
Interventions
DRUG

Crenolanib

Crenolanib will be administered orally

DRUG

Cytarabine

"HAM regimen~FLAG-Ida"

DRUG

Mitoxantrone

HAM regimen

DRUG

Placebo Oral Tablet

Placebo will be administered orally

DRUG

Fludarabine

FLAG-Ida regimen

DRUG

Idarubicin

FLAG-Ida regimen

DRUG

G-CSF

FLAG-Ida regimen

Trial Locations (62)

10003

RECRUITING

San Pedro de Alcantara Hospital, Cáceres

10126

RECRUITING

A.O.U. Città della Salute e della Scienza di Torino, Torino

10128

RECRUITING

AO Ordine Mauriziano di Torino, Torino

13009

RECRUITING

Institut Paoli-Calmettes, Marseille

14004

RECRUITING

Reina Sofia University Hospital, Córdoba

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15006

RECRUITING

Complejo Hospitalario Universitario A Coruna, A Coruña

15706

RECRUITING

Hospital Clinico Universitario de Santiago, Santiago de Compostela

20014

RECRUITING

Hospital Universitario de Donostia, Donostia / San Sebastian

20122

RECRUITING

IRCCS Foundation Ca 'Granda Ospedale Maggiore Policlinico, Milan

20132

RECRUITING

IRCCS San Raffaele Hospital, Milan

20141

RECRUITING

Istituto Europeo di Oncologia, Milan

25123

RECRUITING

ASST Spedali Civili di Brescia, Brescia

27104

RECRUITING

Wake Forest Baptist Medical Center, Winston-Salem

28034

RECRUITING

Hospital Ramon y Cajal, Madrid

28040

RECRUITING

Fundacion Jimenez Diaz, Madrid

28041

RECRUITING

Hospital 12 de Octubre, Madrid

28046

RECRUITING

Hospital Universitario La Paz, Madrid

28100

RECRUITING

AOU Maggiore della Carità, Novara

31059

RECRUITING

Institut Universitaire du Cancer Toulouse, Toulouse

32610

RECRUITING

University of Florida, Gainesville

33011

RECRUITING

Hospital Universitario Central de Asturias (HUCA), Oviedo

33604

RECRUITING

CHU de Bordeaux, Pessac

36100

RECRUITING

AULSS n 8 Berica Ospedale San Bortolo, Vicenza

37007

RECRUITING

Hospital Clinico Universitario de Salamanca, Salamanca

37134

RECRUITING

Policlinico GB Rossi, University Hospital Verona, Verona

38043

RECRUITING

CHU Grenoble Alpes, Grenoble

39008

RECRUITING

Hospital U. Marques de Valdecilla, Santander

40138

RECRUITING

AOU Policlinico Sant'Orsola-Malpighi, Bologna

41013

RECRUITING

Hospital U. Virgen del Rocio, Seville

44093

RECRUITING

CHU de Nantes - Hôtel Dieu, Nantes

45147

RECRUITING

Universitätsklinikum Essen (AöR), Essen

46026

RECRUITING

Hospital Universitario y Politecnico La Fe, Valencia

47014

RECRUITING

IRST - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

48121

RECRUITING

Ospedale Santa Maria delle Croci di Ravenna, Ravenna

48149

RECRUITING

Universitätsklinikum Münster, Münster

48201

RECRUITING

Karmanos Cancer Center, Detroit

48202

RECRUITING

Henry Ford Health System, Detroit

50134

RECRUITING

AOU Careggi, Florence

59037

RECRUITING

Hospital Claude Huriez - Chru Lille, Lille

60637

RECRUITING

University of Chicago, Chicago

61122

RECRUITING

AO Ospedali Riuniti Marche Nord, Pesaro

69494

RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

75010

RECRUITING

Hôpital St Louis, Paris

78157

RECRUITING

Hospital Center of Versailles (Le Chesnay), Le Chesnay

80131

RECRUITING

Aorn Antonio Cardarelli, Napoli

RECRUITING

AOU Federico II, Napoli

86021

RECRUITING

CHU de Poitiers, Poitiers

93000

RECRUITING

Hospital Avicenne, Bobigny

95817

RECRUITING

City of Hope National Medical Center, Sacramento

RECRUITING

UC Davis Comprehensive Cancer Center, Sacramento

666160

RECRUITING

Kansas University, Kansas City

T6G 2R3

RECRUITING

University of Alberta, Edmonton

06200

RECRUITING

University Hospital Nice L'Archet, Nice

09116

RECRUITING

Klinikum Chemnitz gGmbH, Chemnitz

Unknown

RECRUITING

Technische Universität Dresden, Dresden

RECRUITING

Universitätsklinikum Frankfurt, Frankfurt

RECRUITING

Universitätsklinikum Halle (Saale), Halle

RECRUITING

AO Ospedali Riuniti Villa Sofia-Cervello, Palermo

RECRUITING

Hospital Gregorio Maranon Servicio de Hematologia y Hemoterapia, Madrid

00133

RECRUITING

Policlinico Tor Vergata, Roma

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli, Roma

Sponsors
All Listed Sponsors
lead

Arog Pharmaceuticals, Inc.

INDUSTRY

NCT03250338 - Study Investigating the Efficacy of Crenolanib With Chemotherapy vs Chemotherapy Alone in R/R FLT3 Mutated AML | Biotech Hunter | Biotech Hunter