Prognostic Value of Ventricular Fibrillation Spectral Analysis in Sudden Cardiac Death

CompletedOBSERVATIONAL
Enrollment

168

Participants

Timeline

Start Date

June 30, 2016

Primary Completion Date

September 30, 2022

Study Completion Date

March 31, 2023

Conditions
Sudden Cardiac DeathVentricular FibrillationReperfusion Injury
Interventions
DIAGNOSTIC_TEST

Spectral analysis of ventricular fibrillation tracings

Up to 5-s long ventricular fibrillation segments will be extracted after segmentation and signal codification from artifact-free tracings. Signals will be band-pass filtered between 1.5 and 40 Hz. Averaged power spectral density will be obtained at each frequency using the non-parametric Welch method for using fast Fourier transform and normalized to the peak power in the 1.5-10 Hz band for each patient. Dominant frequency, HL-PSDR (the relative power between high and low frequency bands (cut-off: 3.9 Hz)) and HL-pKR ( relative number of spectral peaks above and below the 3.9 Hz threshold with power above 40% the frequency with the highest power), along with the number of DC shocks before ROSC, will be the variables used to obtain a model-derived risk score for outcome prediction.

Trial Locations (5)

13005

Hospital General Universitario de Ciudad Real, Ciudad Real

28007

Hospital General Universitario Gregorio Marañón, Madrid

28029

Fundación Centro Nacional de Investigaciones Cardiovasculares, Carlos III, Madrid

28040

Hospital Clínico San Carlos, Madrid

28046

Hospital Universitario La Paz, Madrid

All Listed Sponsors
collaborator

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III

OTHER

collaborator

Hospital Universitario La Paz

OTHER

collaborator

Hospital General de Ciudad Real

OTHER

collaborator

Fundación de Investigación en Red en Enfermedades Cardiovasculares

OTHER

collaborator

Hospital General Universitario Gregorio Marañon

OTHER

collaborator

Spanish Society of Cardiology

OTHER

collaborator

Fundacion Investigacion Interhospitalaria Cardiovascular

OTHER

lead

Hospital San Carlos, Madrid

OTHER

NCT03248557 - Prognostic Value of Ventricular Fibrillation Spectral Analysis in Sudden Cardiac Death | Biotech Hunter | Biotech Hunter