Effects of Flavors on Nicotine Reinforcement in Smokers

EARLY_PHASE1CompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

April 23, 2018

Primary Completion Date

December 19, 2018

Study Completion Date

January 31, 2019

Conditions

Nicotine Dependence

Interventions

DRUG

IV nicotine

Subjects in each arm will receive three infusions in a random order one hour apart. The infusions will be saline, 0.25mg/70kg and 0.5mg/70kg

DRUG

Menthol flavor

American e-liquids' menthol flavor used in e-cigarettes will be used as the placebo comparator

DRUG

green apple

green apple will be added to the menthol flavor

DRUG

green apple and menthol

menthol and green apple will be the active intervention

Trial Locations (1)

Veterans Affairs, West Haven

All Listed Sponsors

collaborator

National Institute on Drug Abuse (NIDA)

NIH

lead

Yale University

OTHER

NCT03243630 - Effects of Flavors on Nicotine Reinforcement in Smokers | Biotech Hunter | Biotech Hunter