First Line mFOLFOXIRI + PANITUMUMAB vs mFOLFOX + PANITUMUMAB IN RAS AND BRAF WT METASTATIC COLORECTAL CANCER PATIENTS

6 mg/kg iv over 60 minutes, day 1

150 mg/sqm iv over 60 minutes day 1

85 mg/sqm iv over 2 hours day 1

200 mg/sqm iv over 2 hours

400 mg/sqm iv bolus, day 1 followed by 2400 mg/sqm 48 h-continuous infusion, starting on day 1;