Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

July 16, 2018

Primary Completion Date

October 1, 2022

Study Completion Date

September 18, 2026

Conditions
Biphasic MesotheliomaEpithelioid MesotheliomaStage I Pleural Malignant Mesothelioma AJCC v7Stage IA Pleural Malignant Mesothelioma AJCC v7Stage IB Pleural Malignant Mesothelioma AJCC v7Stage II Pleural Malignant Mesothelioma AJCC v7Stage III Pleural Malignant Mesothelioma AJCC v7
Interventions
DRUG

Atezolizumab

Given IV

DRUG

Cisplatin

Given IV

PROCEDURE

Extrapleural Pneumonectomy

Undergo EPP

DRUG

Pemetrexed Disodium

Given IV

PROCEDURE

Pleurectomy

Undergo PD

RADIATION

Radiation Therapy

Undergo RT

Trial Locations (177)

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

22908

University of Virginia Cancer Center, Charlottesville

29425

Medical University of South Carolina, Charleston

32207

Baptist MD Anderson Cancer Center, Jacksonville

37343

Pulmonary Medicine Center of Chattanooga-Hixson, Hixson

37363

Memorial GYN Plus, Ooltewah

37404

Memorial Hospital, Chattanooga

40004

Flaget Memorial Hospital, Bardstown

40165

Jewish Hospital Medical Center South, Shepherdsville

40202

Jewish Hospital, Louisville

40215

Saints Mary and Elizabeth Hospital, Louisville

40245

UofL Health Medical Center Northeast, Louisville

40504

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40701

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48202

Henry Ford Hospital, Detroit

48315

Henry Ford Macomb Health Center - Shelby Township, Shelby

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

49201

Allegiance Health, Jackson

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50266

Mercy Medical Center-West Lakes, West Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

51503

Alegent Health Mercy Hospital, Council Bluffs

55905

Mayo Clinic in Rochester, Rochester

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60504

Rush-Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62226

Southwest Illinois Health Services LLP, Swansea

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63080

Missouri Baptist Sullivan Hospital, Sullivan

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

Missouri Baptist Medical Center, St Louis

63628

Parkland Health Center-Bonne Terre, Bonne Terre

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Mercy Cancer Center - Cape Girardeau, Cape Girardeau

Saint Francis Medical Center, Cape Girardeau

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

66044

Lawrence Memorial Hospital, Lawrence

67208

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

68046

Midlands Community Hospital, Papillion

68122

Alegent Health Immanuel Medical Center, Omaha

Hematology and Oncology Consultants PC, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68803

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island

68845

Fred and Pamela Buffett Cancer Center - Kearney, Kearney

68847

CHI Health Good Samaritan, Kearney

70121

Ochsner Medical Center Jefferson, New Orleans

71913

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73505

Cancer Centers of Southwest Oklahoma Research, Lawton

75080

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

M D Anderson Cancer Center, Houston

77079

MD Anderson West Houston, Houston

77384

MD Anderson in The Woodlands, Conroe

77478

MD Anderson in Sugar Land, Sugar Land

77573

MD Anderson League City, League City

77802

Saint Joseph Regional Cancer Center, Bryan

80122

AdventHealth Littleton, Littleton

80138

AdventHealth Parker, Parker

Rocky Mountain Cancer Centers-Parker, Parker

80210

AdventHealth Porter, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

Saint Anthony Hospital, Lakewood

80260

Rocky Mountain Cancer Centers-Thornton, Thornton

80401

Mountain Blue Cancer Care Center, Golden

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81008

Rocky Mountain Cancer Centers - Pueblo, Pueblo

81301

CommonSpirit Cancer Center Mercy, Durango

Mercy Medical Center, Durango

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83642

Idaho Urologic Institute-Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

85054

Mayo Clinic Hospital in Arizona, Phoenix

85259

Mayo Clinic in Arizona, Scottsdale

89052

Comprehensive Cancer Centers of Nevada - Henderson, Henderson

OptumCare Cancer Care at Seven Hills, Henderson

89102

OptumCare Cancer Care at Charleston, Las Vegas

89106

Radiation Oncology Centers of Nevada Central, Las Vegas

89109

GenesisCare USA - Las Vegas, Las Vegas

89119

Radiation Oncology Centers of Nevada Southeast, Las Vegas

89128

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas

OptumCare Cancer Care at MountainView, Las Vegas

89135

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas

89144

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas

89148

Comprehensive Cancer Centers of Nevada, Las Vegas

OptumCare Cancer Care at Fort Apache, Las Vegas

89169

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

89502

Renown Regional Medical Center, Reno

89503

Saint Mary's Regional Medical Center, Reno

89509

Radiation Oncology Associates, Reno

91010

City of Hope Comprehensive Cancer Center, Duarte

93420

PCR Oncology, Arroyo Grande

95817

University of California Davis Comprehensive Cancer Center, Sacramento

98003

Saint Francis Hospital, Federal Way

98004

Overlake Medical Center, Bellevue

98022

Saint Elizabeth Hospital, Enumclaw

98055

Valley Medical Center, Renton

98109

Fred Hutchinson Cancer Center, Seattle

98166

Highline Medical Center-Main Campus, Burien

98195

University of Washington Medical Center - Montlake, Seattle

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98383

Saint Michael Cancer Center, Silverdale

98405

Franciscan Research Center-Northwest Medical Plaza, Tacoma

Northwest Medical Specialties PLLC, Tacoma

98499

Saint Clare Hospital, Lakewood

77026-1967

Lyndon Baines Johnson General Hospital, Houston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH