Volatiles in Breath and Headspace Analysis - Diagnostic Markers

Enrolling by invitationOBSERVATIONAL
Enrollment

3,000

Participants

Timeline

Start Date

July 24, 2017

Primary Completion Date

December 20, 2019

Study Completion Date

December 31, 2025

Conditions
TuberculosisGastric CancerPeptic UlcerAtrophic GastritisIntestinal MetaplasiaGastric DysplasiaColorectal CancerColorectal PolypColorectal AdenomaPancreatic CancerPancreatitis, ChronicLiver CancerLiver CirrhosisFlu, HumanOther Infectious DiseasesInflammatory Bowel Diseases
Interventions
DIAGNOSTIC_TEST

VOC detection in breath and in skin headspace

VOC will be detected in breath with off-line and on-line testing and in skin headspace with off-line testing

DIAGNOSTIC_TEST

Breath sampling

Breath sampling for VOCs detections will be carried out using nano-sensor based devices (electronic nose)

PROCEDURE

Upper endoscopy with biopsies

Upper endoscopy with proper biopsy work-up will be used for identification and stratification of gastric lesions as well as acquisition of biopsies for microbiota testing

PROCEDURE

Colonoscopy with biopsies

Colonoscopy with proper biopsy or polypectomy material work-up will be used for identification and stratification of colorectal lesions as well as acquisition of biopsies for microbiota testing

PROCEDURE

Whole blood/ Plasma / serum sampling

Whole blood/Plasma/serum sampling will be used to obtain information for group stratification

DIAGNOSTIC_TEST

Faecal sampling

Facal samples will be obtained for faecal occult blood testing as well as microbiota analysis

PROCEDURE

Histological examination of surgical specimen

Routine histological exam for patients undergoing curative or palliative surgery. Indication for surgery are set based on underlying condition. Study does not interfere with decision making for surgical treatment

DIAGNOSTIC_TEST

Headspace analysis for biological material

VOC analysis from headspace of surgical specimen, biopsy materials, blood/plasma, microbiota etc.

Trial Locations (1)

LV 1586

University of Latvia, Riga

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Technion, Israel Institute of Technology

OTHER

collaborator

Riga East University Hospital

UNKNOWN

collaborator

JLM Innovation GmbH

UNKNOWN

lead

University of Latvia

OTHER

NCT03228095 - Volatiles in Breath and Headspace Analysis - Diagnostic Markers | Biotech Hunter | Biotech Hunter