Rechallenge With Panitumumab Driven by RAS Dynamic of Resistance

PHASE2CompletedINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

October 11, 2017

Primary Completion Date

November 6, 2019

Study Completion Date

December 31, 2021

Conditions
Colorectal Cancer
Interventions
DRUG

Panitumumab 20 MG/ML Intravenous Solution [VECTIBIX]

Panitumumab 6 mg/kg in 100 cc 0.9% NaCl solution on Day 1 every two weeks by IV administration over 1 hour.

DIAGNOSTIC_TEST

Molecular Screening

Patients without plasmatic evidence of potentially resistant clones harbouring RAS or EGFR-ectodomain mutations in the RML liquid biopsy, will be molecular eligible for the trial phase

Trial Locations (4)

10060

Fondazione del Piemonte per l'Oncologia - IRCCS, Candiolo

20133

Istituto Nazionale Tumori - IRCCS, Milan

35128

Istituto Oncologico Veneto - IRCCS, Padua

Unknown

Grande Ospedale Metropolitano Niguarda, Milan

All Listed Sponsors
lead

Fondazione del Piemonte per l'Oncologia

OTHER

NCT03227926 - Rechallenge With Panitumumab Driven by RAS Dynamic of Resistance | Biotech Hunter | Biotech Hunter