A Study of VX-445 in Healthy Subjects and Subjects With Cystic Fibrosis

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

225

Participants

Timeline

Start Date

January 23, 2017

Primary Completion Date

March 27, 2018

Study Completion Date

March 27, 2018

Conditions
Cystic Fibrosis
Interventions
DRUG

IVA

IVA tablet for oral administration

DRUG

TEZ/IVA

TEZ/IVA fixed-dose combination for oral administration.

DRUG

VX-445

VX-445 tablet for oral administration.

DRUG

Matched Placebo

Matched placebo.

DRUG

TEZ

Tablet for oral administration.

DRUG

VX-561

Tablet for oral administration.

DRUG

VX-445

VX-445 IV injection

Trial Locations (38)

22908

University of Virginia Health System, Charlottesville

23298

Virginia Commonwealth University, Richmond

23507

Children's Hospital of the King's Daughters, Norfolk

26506

West Virginia University Hospitals, Morgantown

30324

Children's Specialty Services at North Druid Hills, Atlanta

32803

Central Florida Pulmonary Group, Orlando

33606

Tampa General Hospital Cardiac and Lung Transplant Clinic, Tampa

43205

Nationwide Children's Hospital, Columbus

44106

University Hospitals Cleveland Medical Center/Rainbow Babies and Children's Hospital, Cleveland

45267

UC Health Office of Clinical Research, Cincinnati

47710

Covance Clinical Research Unit Inc., Evansville Clinic [Parts A, B, C only], Evansville

48201

Harper University Hospital, Detroit

53226

Medical College of Wisconsin, Milwaukee

55404

Children's Respiratory and Critical Care Specialists, P.A., Children's Hospitals and Clinics of Minn, Minneapolis

60611

Northwestern Memorial Hospital, Chicago

66160

University of Kansas Medical Center, Kansas City

70112

Tulane Medical Center, New Orleans

72205

University of Arkansas for Medical Sciences, Little Rock

78723

Austin Children's Chest Associates, Austin

80206

National Jewish Health, Denver

85724

Banner University of Arizona Medical Center, Tucson

87131

University of New Mexico School of Medicine, Albuquerque

93636

Valley Children's Healthcare, Madera

96411

(Kaiser Permanente) Oakland Medical Center, Oakland

07960

Morristown Medical Center, Morristown

05401

The University of Vermont, Burlington

Unknown

Monash Medical Center, Clayton

The Alfred Hospital, Melbourne

The Royal Children's Hospital Melbourne, Parkville

Mater Adult Hospital, Brisbane

Royal Prince Alfred Hospital, Sydney

Westmead Hospital, Sydney

Antwerp University Hospital, Edegem

Universitair Ziekenhuis Gent, Ghent

Academic Medical Centre, Amsterdam

Radboud UMC, Nijmegen

Erasmus Medical Center, Rotterdam

HagaZiekenhuis van den Haag, The Hague

All Listed Sponsors
lead

Vertex Pharmaceuticals Incorporated

INDUSTRY

NCT03227471 - A Study of VX-445 in Healthy Subjects and Subjects With Cystic Fibrosis | Biotech Hunter | Biotech Hunter