Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

January 5, 2018

Primary Completion Date

October 1, 2026

Study Completion Date

August 1, 2028

Conditions
BRAF V600E Mutation PresentPapillary Craniopharyngioma
Interventions
DRUG

Vemurafenib

Given PO

DRUG

Cobimetinib

Given PO

OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Quality-of-Life Assessment

Ancillary studies

Trial Locations (106)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10065

NYP/Weill Cornell Medical Center, New York

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22031

Inova Schar Cancer Institute, Fairfax

26101

Camden Clark Medical Center, Parkersburg

26330

United Hospital Center, Bridgeport

26506

West Virginia University Healthcare, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33606

Tampa General Hospital, Tampa

35233

University of Alabama at Birmingham Cancer Center, Birmingham

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49048

Borgess Medical Center, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

Trinity Health Muskegon Hospital, Muskegon

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

53215

Aurora Saint Luke's Medical Center, Milwaukee

54017

Cancer Center of Western Wisconsin, New Richmond

55082

Lakeview Hospital, Stillwater

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

Minnesota Oncology - Burnsville, Burnsville

55362

Monticello Cancer Center, Monticello

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

55905

Mayo Clinic in Rochester, Rochester

56201

Rice Memorial Hospital, Willmar

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60612

Rush University Medical Center, Chicago

63110

Washington University School of Medicine, St Louis

64132

Research Medical Center, Kansas City

65613

Central Care Cancer Center - Bolivar, Bolivar

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73505

Cancer Centers of Southwest Oklahoma Research, Lawton

77030

M D Anderson Cancer Center, Houston

82801

Welch Cancer Center, Sheridan

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83642

Idaho Urologic Institute-Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

84009

South Jordan Health Center, South Jordan

84025

Farmington Health Center, Farmington

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94010

Mills-Peninsula Medical Center, Burlingame

94040

Palo Alto Medical Foundation-Camino Division, Mountain View

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

California Pacific Medical Center-Pacific Campus, San Francisco

94301

Palo Alto Medical Foundation Health Care, Palo Alto

94546

Eden Hospital Medical Center, Castro Valley

94589

Sutter Solano Medical Center/Cancer Center, Vallejo

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95355

Memorial Medical Center, Modesto

95603

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn

95661

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

Sutter Roseville Medical Center, Roseville

95682

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park

95687

Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville

95816

Sutter Medical Center Sacramento, Sacramento

98109

FHCC South Lake Union, Seattle

Fred Hutchinson Cancer Center, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

32224-9980

Mayo Clinic in Florida, Jacksonville

02111

Tufts Medical Center, Boston

02114

Massachusetts General Hospital Cancer Center, Boston

02215

Dana-Farber Cancer Institute, Boston

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07101

Rutgers New Jersey Medical School, Newark

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER

NCT03224767 - Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma | Biotech Hunter | Biotech Hunter