A Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in Combination With Ruxolitinib in Participants With Myelofibrosis

PHASE2CompletedINTERVENTIONAL
Enrollment

191

Participants

Timeline

Start Date

October 31, 2017

Primary Completion Date

March 28, 2022

Study Completion Date

January 29, 2025

Conditions
Myelofibrosis (MF)
Interventions
DRUG

Ruxolitinib

Tablet; Oral

DRUG

Navitoclax

Film-coated tablet; Oral

Trial Locations (91)

704

National Cheng Kung University Hospital /ID# 230372, Tainan City

833

Kaohsiung Chang Gung Memorial Hospital /ID# 230371, Kaohsiung City

1085

Semmelweis Egyetem /ID# 230518, Budapest

1097

Duplicate_Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet /ID# 230306, Budapest

2010

The Kinghorn Cancer Centre /ID# 214657, Darlinghurst

3000

Peter MacCallum Cancer Ctr /ID# 218352, Melbourne

3004

The Alfred Hospital /ID# 215545, Melbourne

3220

Barwon Health /ID# 222430, Geelong

4400

Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 230585, Nyíregyháza

6150

Fiona Stanley Hospital /ID# 216809, Murdoch

10000

Clinical Hospital Dubrava /ID# 230504, Zagreb

Klinicka bolnica Merkur /ID# 230599, Zagreb

Klinicki bolnicki centar Zagreb /ID# 230602, Zagreb

10065

Weill Cornell Medical College /ID# 162679, New York

11527

General Hospital of Athens Laiko /ID# 230394, Athens

12462

Duplicate_University General Hospital Attikon /ID# 230395, Athens

20817

Duplicate_American Oncology Partners of Maryland, PA /ID# 231299, Bethesda

21000

Klinicki Bolnicki Centar (KBC) Split /ID# 230601, Split

21100

ASST Sette Laghi - Ospedale Di Circolo E Fondazione Macchi Varese /ID# 214551, Varese

24127

ASST Papa Giovanni XXIII /ID# 214900, Bergamo

25123

ASST degli Spedali Civili di Brescia /ID# 230420, Brescia

28007

Hospital General Universitario Gregorio Maranon /ID# 214676, Madrid

28027

CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 230719, Madrid

28041

Hospital Universitario 12 de Octubre /ID# 214710, Madrid

29010

Hospital Universitario Virgen de la Victoria /ID# 214709, Málaga

29011

Hospital Regional Universitario de Malaga /ID# 230858, Málaga

29425

Duplicate_Medical University of South Carolina /ID# 222597, Charleston

31008

Duplicate_CLINICA UNIVERSIDAD DE NAVARRA-Pamplona /ID# 230718, Pamplona

32224

Mayo Clinic /ID# 164201, Jacksonville

35217

UAB Comprehensive Cancer Cente /ID# 165464, Birmingham

40138

IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 230012, Bologna

46237

Indiana Blood & Marrow Transpl /ID# 165075, Indianapolis

48202

Henry Ford Hospital /ID# 162682, Detroit

50134

Azienda Ospedaliero Universitaria Careggi /ID# 214555, Florence

57201

Prairie Lakes Healthcare System /ID# 224358, Watertown

61761

Mid Illinois Hematology & Oncology Associates, Ltd /ID# 230536, Normal

64132

MidAmerica Division, Inc. /ID# 222058, Kansas City

78229

University of Texas Health San Antonio MD Anderson Cancer Center /ID# 164094, San Antonio

79606

Texas Oncology - West Texas /ID# 224784, Abilene

80218

Colorado Blood Cancer Institute /ID# 224250, Denver

84106

Utah Cancer Specialists Salt Lake Clinic /ID# 222806, Salt Lake City

89125

Grande Ospedale Metropolitano Bianchi - Melacrino - Morelli P.O. Riuniti /ID# 230011, Reggio Calabria

90033

University of Southern California /ID# 164095, Los Angeles

91010

City of Hope /ID# 221395, Duarte

91120

Hadassah Medical Center-Hebrew University /ID# 230310, Jerusalem

92093

Moores Cancer Center at UC San Diego /ID# 164084, La Jolla

95123

AOU Policlinico G. Rodolico - San Marco /ID# 214549, Catania

97701

Bend Memorial Clinic /ID# 224184, Bend

2210001

Galilee Medical Center /ID# 230397, Nahariya

6423906

Tel Aviv Sourasky Medical Center /ID# 230311, Tel Aviv

7747629

Assuta Ashdod Medical Center /ID# 230396, Ashdod

90703-2679

TOI Clinical Research /ID# 222546, Cerritos

90806-1701

Long Beach Memorial Medical Ct /ID# 230148, Long Beach

32207-8432

Baptist MD Anderson Cancer Center - Jacksonville /ID# 222548, Jacksonville

33612-9416

Moffitt Cancer Center /ID# 164082, Tampa

60637-1426

University of Chicago Medicine /ID# 164115, Chicago

02215

Dana-Farber Cancer Institute /ID# 162675, Boston

01655

University of Massachusetts - Worcester /ID# 222547, Worcester

48075-3707

Ascension Providence Southfield Cancer Center /ID# 223876, Southfield

43210-1280

The Ohio State University /ID# 217402, Columbus

15224-1722

West Penn Hospital /ID# 222618, Pittsburgh

37203-1632

Tennessee Oncology-Nashville Centennial /ID# 221410, Nashville

75246-2003

Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 225159, Dallas

77030-3306

Oncology Consultants /ID# 230930, Houston

77030-4000

MD Anderson Cancer Center at Texas Medical Center /ID# 162683, Houston

84112-5500

University of Utah /ID# 164116, Salt Lake City

T6G 2B7

Duplicate_University of Alberta Hospital - Division of Hematology /ID# 217698, Edmonton

M5G 2M9

University Health Network_Princess Margaret Cancer Centre /ID# 214483, Toronto

H4A 3J1

McGill University Health Center Research Institute /ID# 223976, Montreal

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 214553, Rome

470-1192

Fujita Health University Hospital /ID# 221539, Toyoake

030-8553

Aomori Prefectural Central Hospital /ID# 221773, Aomori

812-8582

Kyushu University Hospital /ID# 222691, Fukuoka

003-0006

Sapporo Hokuyu Hospital /ID# 222693, Sapporo

573-1191

Kansai Medical University Hospital /ID# 222690, Hirakata-shi

589-8511

Kindai University Hospital /ID# 222689, Osakasayama-shi

343-8555

Duplicate_Dokkyo Medical University Saitama Medical Center /ID# 222332, Koshigaya-shi

113-8431

Juntendo University Hospital /ID# 221484, Bunkyo-ku

113-8602

Nippon Medical School Hospital /ID# 222692, Bunkyo-ku

409-3821

University of Yamanashi Hospital /ID# 221700, Chuo-shi

00921-3201

VA Caribbean Healthcare System /ID# 222416, San Juan

00927

Hospital del Centro Comprensivo de Cancer de la UPR /ID# 222544, San Juan

03080

Seoul National University Hospital /ID# 230380, Seoul

06351

Samsung Medical Center /ID# 230381, Seoul

08916

Hospital Universitario Germans Trias i Pujol /ID# 214704, Badalona

08035

Hospital Universitario Vall d'Hebron /ID# 222415, Barcelona

SE1 9RT

Guys and St Thomas NHS Foundation Trust /ID# 164110, London

OX3 9DU

Oxford University Hospitals NHS Foundation Trust /ID# 214503, Oxford

BT9 7AB

Belfast Health and Social Care Trust /ID# 216991, Belfast

M20 4BX

The Christie Hospital /ID# 164111, Manchester

NP18 3XQ

Aneurin Bevan University Health Board /ID# 230332, Newport

Sponsors

Lead Sponsor

All Listed Sponsors
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AbbVie

INDUSTRY